Gene and Cell Delivery for Intervertebral Disc Degeneration Gene and Cell Therapy Series
Coordonnateurs : Gonçalves Raquel Madeira, Barbosa Mario Adolfo
Intervertebral disc degeneration is one of the major causes of lower back pain for which the common therapeutic interventions are not efficient. A search for alternative therapies for lower back pain and intervertebral disc degeneration includes cell-based therapies. Unfortunately, intervertebral disc degeneration is avascular and thus a hostile environment for cell survival. Furthermore, cellular characterization in intervertebral disc degeneration, and particularly in the nucleus pulposus, is controversial, mainly due to lack of specific markers and species variability. This book adds to the knowledge on cellular and molecular therapies for intervertebral disc degeneration and associated lower back pain.
Key Selling Features:
- Describes the ontogeny and phenotype of intervertebral disc cells
- Reviews the role that inflammation plays in disco-genic pain
- Highlights the types of cells that might be used as sources for treating degenerating intervertebral discs
- Summarizes current alternative therapies
- Explores methods for cell delivery into degenerated intervertebral discs
Intervertebral disc degeneration in the clinics: therapeutic challenges. Cell therapies and pain in low back pain patients. Molecular therapy for intervertebral disc degeneration. Cell therapies for intervertebral disc with activated Nucleus Pulposus Cells. Mesenchymal Stem Cells-based therapies for intervertebral disc . Materials for cell delivery in degenerated intervertebral disc. Chemoattractors in intervertebral disc degeneration. Cell recruitment for degenerated intervertebral disc. Cell therapies and mechanotransduction in degenerated intervertebral disc. Molecular therapies with miRNA in degenerated intervertebral disc.
Raquel M. Gonçalves has a degree in chemical engineering and a PhD in biotechnology (University of Lisbon, Portugal). She gained expertise in human hematopoietic stem cell and mesenchymal stem cell expansion, with a period abroad in the University of Nevada, Reno, United States. Since 2009, she has been an assistant investigator and has been dedicated to intervertebral disc research. Presently, at I3S (Instituto de Investigação e Inovação em Saúde/INEB, Institute of Biomedical Engineering, University of Porto), she develops her work at the Microenvironments for New Therapies Group, whose main goal is to dissect the microenvironment elements that contribute to reestablish homeostasis upon disease and/or injury and to bioengineer therapeutic strategies to modulate host response. In this group, she has been involved in the establishment of IVD ex vivo and in vivo models, highthroughput tools to characterize IVD cells and extracellular matrix, and immunomodulatory strategies and stem cell recruitment to degenerated IVD. In parallel, she is involved in science dissemination activities at Porto high schools and in teaching at the University of Porto.
Mário Adolfo Barbosa is a full professor at Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, Portugal. For nearly 30 years, biomaterials science and technology has been the topic of Mário’s research. He is internationally recognized for his contributions to biomaterials science, particularly in cell– biomaterial interactions. Mário was one of the founding members of the Instituto de Engenharia Biomédica (INEB, http://www.ineb.up.pt), created in June 1989. From 2000 to 2012, he was the scientific coordinator of the institute and its president from 2000–2006 and 2010–2012. Presently, he is the scientific coordinator of the I3S (Instituto de Investigação e Inovação em Saúde), of the University of Porto and leader of the Microenvironments for New Therapies Group at i3S. His research interests
Date de parution : 03-2021
15.6x23.4 cm
Date de parution : 05-2018
15.6x23.4 cm
Thèmes de Gene and Cell Delivery for Intervertebral Disc Degeneration :
Mots-clés :
Multipotent Mesenchymal Stromal Cells; AF Cell; Catarina Leite Pereira; CCL20 Expression; Catherine Le Visage; Oswestry Disability Index; Delphine Logeart-Avramoglou; Np Cell; Esther Potier; CXCR4 Expression; AAV Vector; Graciosa Q; Teixeira; Human Np Cell; Jerome Guicheux; IVD Degenerative; Joana Silva-Correia; Disc Degeneration; Joaquim Miguel Oliveira; MR Elastography; Johann Clouet; Human Np; Luca Ambrosio; Transplanted Adult Stem Cells; Marianna Peroglio; AF Tissue; Marion Fusellier; Intradiscal Injection; M?O Adolfo Barbosa; Lumbar DDD; Olivier Gauthier; CXCR4 Axis; Paulo Pereira; Human IVDs; Pedro Santos Silva; Adult Stem Cells; Raquel M; GonVes; IVD Cell; Rui LuReis; Discogenic Pain; Rui Vaz; Np Tissue; Sebastian Wangler; Total Gag Content; Sibylle Grad; T2 Relaxation Time; Vincenzo Denaro; Notochordal Cells; Zhen Li; lower back pain; intervertebral disc cells; disco-genic pain; cell-based therapies; molecular therapies