Fundamentals of Toxicologic Pathology (3rd Ed.)
Coordonnateurs : Wallig Matthew A., Bolon Brad, M Haschek Wanda, Rousseaux Colin G.
Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development.
The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others.
1. Overview of Toxicological Pathology
Part I: Principles of Toxicologic Pathology2. Biochemical and Molecular Basis of Toxicity3. Pharmacokinetics & Toxicokinetics 4. Principles of Pharmacodynamics & Toxicodynamics5. Morphologic Manifesations of Toxic Cell Injury6. Carcinogenesis: Mechanisms and Manifestation7. Design of Studies & Risk Management in Toxicologic Pathology
Part II: Systems Toxicologic Pathology8. Hepatobiliary System9. Cardiovascular System10. Muscular System11. Urinary System12. Immune System13. Hematopoietic System14. Respiratory Tract15. Digestive Tract16. Exocrine Pancreas17. Male Reproductive System18. Female Reproductive System19. Mammary Gland20. Endocrine System21. Nervous System22. Special Senses: Ocular Sytem22b. Special Senses: Auditory System23. Skeletal System (Bone & Joint)24. Integumentary System25. Embryo, Fetus & Placenta
Toxicologists, toxicologic pathologists, medical doctors, veterinary pathologists, graduate students, and those working in regulatory affairs, pharmacology, pharmacokinetics, animal models, or clinical development
Brad Bolon, DVM, MS, Ph.D., DAVCP, DABT, FATS, FIATP, FRCPath, has worked [sic] as an experimental and toxicologic pathologist in several settings: academia, a contract research organization, pharmaceutical companies (in both biomolecule and traditional small molecule settings), and private consulting. His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, and placentas) and toxicologic neuropathology to assess the efficacy and safety of many therapeutic entities (biomolecules, cell and gene therapies, medical devices, and small molecules). He is a former President of the STP and a Member of the American College of Toxicology (ACT), British Society of Toxicological Pathology (BSTP), and European Society of Toxicologic Pathology (ESTP). Brad served as an Editor for the third edition of the Fundamentals of Toxicologic Pathology and an Associate Editor for the third edition of Haschek and Rousseaux’s Handbook of Toxicologic Pathology.
Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and
- Presents revised and updated information for each chapter on systems
- Contains expanded sections on applied toxicologic pathology
- Includes the essential information necessary to understand toxicologic pathology in an accessible language
Date de parution : 12-2017
Ouvrage de 902 p.
21.4x27.6 cm
