Fluorescence Imaging for Surgeons, Softcover reprint of the original 1st ed. 2015 Concepts and Applications

This text presents the experiences of leading researchers and surgeons with different fluorescence methods. Chapters range from basic science of fluorescence to current clinical applications and new horizons. The first few chapters describe the historical evolution and physical principles of fluorescence and provide the foundation for the reader to understand the current scope and limits of its use in surgery. The second section focuses on the clinical applications of intraoperative fluorescence imaging including subsections on fluorescence cholangiography, applications to hepatectomy, lymph node navigation, applications to GI tract and pelvic surgery and identification of cancer tissues. The third section focuses on new frontiers including fluorescence probes, imaging systems and applications to photodynamic therapy.

Authored by leaders in the development of fluorescent methods worldwide, Fluorescence Imaging for Surgeons: Concepts and Applications will have an impact on numerous medical specialists including general surgeons, colorectal and minimally-invasive surgeons and surgical oncologists. Researchers will find the book to be an invaluable resource on the latest advances in the utilization of nanoparticles and fluorescent probes.?

Section I: Background

Chapter 1       

Basic Concepts of Fluorescence and Fluorescent Probes

Guillermo O. Menéndez, Federico Coluccio Leskow, and Carla C. Spagnuolo

Chapter 2       

Past, Present and Future of Fluorescence

Daniel Debonis, Pablo Quadri, Manuel Montesinos, Jorge Falco, David Nguyen, Diego Sinagra, Fernando Dip, and Raul J. Rosenthal

Chapter 3       

Translation of Therapeutic Antibodies for Intraoperative Fluorescence Imaging

Eben L. Rosenthal and Jason M. Warram

Chapter 4       

Review of Indocyanine Green Imaging in Surgery

Jarmo T. Alander, Outi M. Villet, Tommi Pätilä^, Ilkka S. Kaartinen, Martin Lehecka, Toshiya Nakaguchi, Taku Suzuki^, and Valery Tuchin

Section II:  Imaging Systems

Chapter 5       

D-Light P System (Karl Storz) (with video)

Rutger M. Schols, Nicole D. Bouvy, Ronald M. van Dam, Laurents P.S. Stassen,

Chapter 6       

Robotic surgery using Firefly System

Giuseppe Spinoglio, Alessandra Marano, Giampaolo Formisano

Chapter 7       

Fluorescence imaging systems (PDE, HyperEye Medical System, and prototypes in Japan)

Takeaki Ishizawa and Norihiro Kokudo

Chapter 8       

The Pinpoint System
Jana L. Lewis and Danny A. Sherwinter

Chapter 9       

Economic Impact of Fluorescent Cholangiography

Emanuele Lo Menzo, Fernando Dip, Samuel Szomstein, and Raul J. Rosenthal

Chapter 10     

Real-time near-infrared fluorescent cholangiography during robotic single-site cholecystectomy

Nicolas C. Buchs

Chapter 11     

Fluorescent guided liver surgery: Paul Brousse experiences and perspective

Mohamed Bekheit and Eric Vibert

Chapter 12     

Fluorescence imaging in laparoscopic hepatectomy (with video)

Yoshikuni Kawaguchi, Takeo Nomi, David Fuks, Norihiro Kokudo, and Brice Gayet

Section III. Clinical Applications of Intraoperative Fluorescence Imaging

Chapter 13     

Identification of hepatic segment (with video)

Masaki Ueno

Chapter 14     

Intraoperative evaluation of regional portal uptake function (with video)

Yoshikuni Kawaguchi, Takeaki Ishizawa, and Norihiro Kokudo

Chapter 15     

Identification of hepatocellular carcinoma (with video)

Yoshifumi Morita, Takanori Sakaguchi, Hirotoshi Kikuchi, Naoki Unno, and Hiroyuki Konno

Chapter 16     

Identification of metastatic liver cancer  (with video)

Henricus J.M. Handgraaf, Floris P.R. Verbeek, Cornelis J.H. van de Velde, Merlijn Hutteman, and Alexander L. Vahrmeijer

Chapter 17     

Prediction for postoperative intrahepatic recurrence of hepatocellular carcinoma
Kunihito Gotoh, Shigeru Marubashi, Terumasa Yamada, Hirofumi Akita, Hidenori Takahashi, Masahiko Yano, Osamu Ishikawa, Masato Sakon

Chapter 18     

Detection of bile leakage after hepatic resection by intraoperative indocyanine green fluorescent imaging

Masaki Kaibori, Kosuke Matsui, Morihiko Ishizaki, Masanori Kwon

Chapter 19     

Near-infrared laser photodynamic therapy for human hepatocellular carcinoma cell line tumor with indocyanine green fluorescence

Junichi Kaneko, Yoshinori Inagaki, Takeaki Ishizawa, Norihiro Kokudo

Chapter 20     

Photodynamic diagnosis of gastric cancer using 5-aminolevulinic acid (with video)

Tsutomu Namikawa, Keiji Inoue, Taro Shuin, and Kazuhiro Hanazaki

Chapter 21     

Applications of ICG Fluorescence Imaging for Surgery in Colorectal cancer

Shingo Shimada, Seiji Ohtsubo, and Mitsuo Kusano

Chapter 22     

Fluorophore-conjugated chimeric anti-CEA antibodies for fluorescence-guided surgery of gastrointestinal (GI) tumors

Michael Bouvet and Robert M. Hoffman

Chapter 23     

Development of a non-blurring, dual-imaging (X-ray/fluorescence) tissue marker for localization of gastrointestinal tumors

Hideki Hayashi, Taro Toyota, Shoichi Goto, Aki Oishi, Tao Gao, Lau Bik Ee, Hisahiro Matsubara

Chapter 24     

Sentinel Node Navigation Surgery by Infrared Imaging in Gastric Cancer

Yoshikazu Uenosono, MD, Takaaki Arigami, Shigehiro Yanagita, Daisuke Matsushita, Sumiya Ishigami, and Shoji Natsugoe

Chapter 25     

A dual infrared ray imaging system for sentinel node mapping against early gastric cancer: absorption and florescence methods by infrared ray electronic endoscopy combined with indocyanine green

Naoto Takahashi, Hiroshi Nimura, Muneharu Fujisaki, Norio Mitsumori, and Katsuhiko Yanaga

Chapter 26     

Indocyanine green fluorescence-navigated sentinel node biopsy showed higher sensitivity than the conventional radioisotope or blue dye methods: it may help to reduce false-negative sentinel lymph node biopsies in skin cancer

Yasuhiro Fujisawa

Chapter 27     

The indocyanine green method is equivalent to the (99m)Tc-labeled radiotracer method for identifying the sentinel node in breast cancer: A concordance and validation study

Bettina Ballardini, Germana Lissidini, and Paolo Veronesi

Chapter 28     

Photodynamic detection of lymph node metastases in gastrointestinal cancer by using 5-aminolevulinic acid

Takeo Minamikawa, Yoshinori Harada, and Tetsuro Takamatsu

Chapter 29     

Application of photodynamic treatment (with video)

Tomás G. Núñez and Tamara Portas

Chapter 30     

Photodynamic diagnosis mediated by 5-aminolevulinic acid for urinary bladder cancer (with video)

Keiji Inoue, Hideo Fukuhara, and Taro Shuin

Chapter 31     

Real-time assessment of intestinal perfusion by fluorescence-based enhanced reality

Michele Diana, Vincent Agnus and Jacques Marescaux

Chapter 32     

Fluorescent angiography for flap planning and monitoring in reconstructive surgery

Georges Bettega, Clotilde Ochala, Marine Hitier, Cynthia Hamou¸ Stéphanie Guillermet, Pascal Gayet, and Jean-Luc Coll

Chapter 33     

Fluorescein-Detection of Myocardial Ischemia in an Experimental Model of Acute Coronary Occlusion
Fernando Dip, Alejandro Damonte, Gaston Quiche, Marcelo Damonte, Fernando M. Safdie, Nicolas Brozzi, and Raul J. Rosenthal

Chapter 34     

Spatial and Temporal Monitoring of Perfusion with Indocyanine GreenVideoangiography in Rat Heart

Outi M. Villet, Jarmo T. Alander, and Ari L. Harjula

Chapter 35     

Ureter identification using methylene blue and fluorescein

Fernando Dip, Alejandro Daniel Moreira Grecco, David Nguyen, Luis Sarotto, Sandy Perrins, and Raul J. Rosenthal

Chapter 36     

Chymotrypsin probe for real-time visualization of pancreatic leak
Suguru Yamashita, Takeaki Ishizawa, Masayo Sakabe, Mako Kamiya, Yasuteru Urano, and Norihiro Kokudo

Fernando Dip, MD, MAAC

The Bariatric and Metabolic Institute

Section of Minimally Invasive Surgery

Department of General and Vascular Surgery

Cleveland Clinic Florida

Weston, FL 

 USA

And

Oncological Surgical Division, Department of Surgery

Division of Surgical Research

Hospital de Clinicas Buenos Aires

University of Buenos Aires

Buenos Aires, Argentina

Takeaki Ishizawa, MD, PhD, FACS

Department of Gastroenterological Surgery, Cancer Institute Hospital

Japanese Foundation for Cancer Reserach

 Koto-ku, Tokyo

Japan

And

Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery

Graduate School of Medicine, The University of Tokyo

Bunkyo-ky, Tokya

Japan

Norihiro Kokudo, MD, PhD, FACS

Professor and Chairman

Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery

Graduate School of Medicine, The University of Tokyo

Bunkyo-ky, Tokya

Japan

Raul J. Rosenthal, MD, FACS

Chief of Staff

The Bariatric & Metabolic Institute

Section of Minimally Invasive Surgery

Department of General & Vascular Surgery

Cleveland Clinic Florida

Weston, FL USA

Authors are leaders in the development of fluorescent methods worldwide

Richly illustrated with photomicrographs, figures and illustrations

Provides the foundation to understand the current scope and limits of the use of fluorescence in surgery