Endothelium Molecular Aspects of Metabolic Disorders
Coordonnateurs : Engin Ayse Basak, Engin Atilla
The function and life span of endothelial cells have a large impact upon the quality and expectancy of an individual's life. During low perfusion, the adaptation of different cells to hypoxia precipitate the aggressive progression of diseases. Although the clinical studies have convincingly shown that endothelial dysfunction occurs whenever the biological functions or bioavailability of nitric oxide are impaired, in all these scenarios, the role of endothelial cell-destructive process cross-talk is yet poorly understood. This book focuses on the contribution of molecular mechanisms to endothelial dysfunction in related metabolic disorders.
Physiological importance of endothelium. Vascular fluid mechanics in the regulation of endothelial function. Ultrastructure of endothelium and endothelial microparticules. Origin of endothelial progenitor cells and their functions. Endothelial dysfunction, cytokines and their genetic variations. Oxidative stress and endothelium: Cellular signaling, nitric oxide and reactive radicals. Asymmetric dimethylarginine and endothelial dysfunction. Endothelial Dysfunction and Diabetes Mellitus. Obesity, metabolic syndrome and endothelium. Vascular endothelium and renin-angiotensin system. Endothelial dysfunction in chronic kidney disease patients and renal transplant recipients: Emerging diagnostic and therapeutic options. Homocysteine and endothelial dysfunction. Oxidative stress and angiogensisis in tumor progression. Nanoparticle: As a messenger between environment and endothelium.
Date de parution : 05-2013
15.6x23.4 cm
Thème d’Endothelium :
Mots-clés :
Endothelial Dysfunction; Endothelial Cells; Physiological Importance of Endothelium; Endothelial Function; Ultrastructure of Endothelium and Microparticles; Endothelial Progenitor Cell; Endothelium and Oxidative Stress; NADPH Oxidase; Endothelial Dysfunction and Diabetes Mellitus; T2 Dm; Oxidative Stress and Angiogenesis in Tumor Progression; T1 Dm; Ang II; RBC Aggregation; Pro-infl Ammatory Cytokines; Proinfl Ammatory Cytokines; HSC; Hematopoietic Progenitor Cells; ADMA Plasma Level; PTRF; Insulin Resistance; PECAM; Atherosclerotic Lesions; Reduce NADPH Oxidase; CKD Patient; Infl Ammatory; AT1 Receptor; Circulate ADMA Level; Uranyl Acetate Lead Citrate; Early EPCs