Cytokines and Chemokines in Autoimmune Disease, Softcover reprint of the original 1st ed. 2003 Advances in Experimental Medicine and Biology Series, Vol. 520

This volume is ideal for individuals interested in taking an in-depth look at how cytokines and chemokines participate in autoimmune disorders, and how cytokines and chemokines can be used as targets for therapeutic intervention. The outstanding features of this book are that it is divided in chapters each focusing on specific, highly prevalent autoimmune disorders. The role of cytokines and chemokines in each of these disorders is dissected in the context of the autoinimune responses that drive these diseases. Importantly, each chapter is meant to provide an in-depth review of how cytokines and chemokines participate in each disease, rather than very specific aspects of cytokine or chemokine biology. The book therefore provides an integrated view of how multiple cytokines and chemokines participate in the initiation and evolution of both systemic and organ-specific pathological immune responses.

I: Autoimmune Diseases, Cytokines and Chemokines.- 1. Cytokines and Chemokines in Autoimmune Disease: An Overview.- 2. Cytokines and Chemokines-Their Receptors and Their Genes: An Overview.- II: Genetics and Mechanisms.- 3. Cytokine and Cytokine Receptor Genes in the Susceptibility and Resistance to Organ-Specific Autoimmune Diseases.- 4. Cytokines, Lymphocyte Homeostasis and Self Tolerance.- 5. The Role of Cytokines as Effectors of Tissue Destruction in Autoimmunity.- 6. Cytokines in the Treatment and Prevention of Autoimmune Responses-A Role of IL-15.- III: Cytokines and Chemokines in Autoimmune Diseases.- 7. Cytokines in the Pathogenesis and Therapy of Autoimmune Encephalomyelitis and Multiple Sclerosis.- 8. Chemokines in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.- 9. Cytokines and Chemokines in the Pathogenesis of Murine Type 1 Diabetes.- 10. Immunoregulation by Cytokines in Autoimmune Diabetes.- 11. Cytokines in the Pathogenesis of Rheumatoid Anhritis and Collagen-Induced Anhritis.- 12. Cytokines and Chemokines in Virus-Induced Autoimmunity.- 13. Cytokines and Chemokines in Human Autoimmune Skin Disorders.- 14. Involvement of Cytokines in the Pathogenesis of Systemic Lupus Erythematosus.- 15. Cytokines, Chemokines and Growth Factors in the Pathogenesis and Treatment ofInflammatory Bowel Disease.