Cytochromes P450 Metabolic and Toxicological Aspects Routledge Revivals Series

First published in 1996: An in-depth book on the role of cytochrome P450 proteins from a toxicological perspective, Cytochromes P450: Metabolics and Toxicological Aspects examines the proteins and their role in toxicity/carcinogenicity and the metabolism of foreign chemicals.

Part 1: General Considerations

1. Cytochrome P450: From a Single Protein to a Family of Proteins-With Some Personal Reflections

R.W. Estabrook

2. Role of Metabolism in Chemical Toxicity

N.P.E. Vermeulen

3.The Chemistry of Cytochrome P450 Reactions

F.P. Guengerich

Part 2: Cytochrome P450 Families/Subfamilies

4. The CYP1 Family

K. Kawajiri and S. i. Hayashi

5. The CYP2A Subfamily

T.H.K. Chang and D.J. Waxman

6. The CYP2B Subfamily

R.W. Nims and R.A. Lubet

7. The CYP2C Subfamily

T.H. Richardson and E.F. Johnson

8. The CYP2D Subfamily

F.J. Gonzalez

9. The CYP2E Subfamily

M.J.J. Ronis, K.O. Lindros, and M. Ingelman-Sundberg

10. The CYP3A Family

P. Maurel

11. The CYP4 Family

B.G. Lake and D.F.V. Lewis

Part 3: Current Issues

12. Expression of Cytochrome P450 Proteins in Disease

C. Ioannides, C.R. Barnett, A. Irizar, and P.R. Flatt

13. Cytochromes P450 and Immunotoxicity

M. Pirmohamed and B.K. Park

14. Molecular Modeling of Mammalian Cytochromes P450

D.F.V. Lewis

Costas Ionnides, Ph.D., is Senior Research Fellow in toxicology in the School of Biological Sciences at the University of Surrey in Guildford, England.