Current Topics in Coronary Research, Softcover reprint of the original 1st ed. 1973 Advances in Experimental Medicine and Biology Series, Vol. 39

How can you adequately honor a man of deeds with mere words? Dr. Donald Eaton Gregg is recognized throughout the scientific world for his distinguished contributions to our knowledge of the coronary circulation, his advances in experimental instrumentation and design, his scientific integrity and his lasting influence on other investigators. His research associates over the years are now liberally scattered over the entire world. Their accomplishments and activities reflect the quality of their training in his Department of Cardiorespiratory Diseases at the Walter Reed Army Institute of Research. The positions of prestige occupied by these men attest to Dr. Gregg's ability to select and inspire men of talent, yet in his usual modest way he insists that he was only fortunate to be in the right place at the right time. Thus, at the time of Dr. Gregg's retirement as Chief of the Department of Cardiorespiratory Diseases, a position he has held since 1950, his associates thought that a scientific symposium was the most appropriate way to honor a man of his stature. Accordingly, on March 29-30, 1973 a Symposium on Current Topics in Coronary Research was held at the Walter Reed Army Institute of Research. Its objectives were to define our present state of knowl­ edge and, more importantly, define the basic questions requiring further experimentation in four major areas of coronary research, i. e.

Section 1: Metabolic Control of Coronary Blood Flow.- Challenges to the Adenosine Hypothesis for the Regulation of Coronary Blood Flow.- Observations on the Effect of Changes in Arterial Oxygenation on Adenosine Induced Coronary Vasodilatation.- Adenosine Metabolism: Properties of Dog Heart Microsomal 5?-Nucleotidase.- Myocardial: Blood Purine Nucleoside Concentration Ratios in Canine Myocardium.- Role of O2 in Control of the Coronary Capillary Reserve.- Coronary and Systemic Hemodynamics in Chemically Sympathectomized Dogs.- Discussion.- Section 2: Transmural Myocardial flow Gradients.- Factors Determining the Distribution and Adequacy of Left Ventricular Myocardial Blood Flow.- Regional Changes in Intramyocardial Pressure Following Myocardial Ischemia.- Discussion.- Section 3: Coronary Collateral Circulation.- Some Developments in the Concept of Collateral Circulation to the Myocardium.- Viewpoint of a Human Pathologist on the Current Coronary Problem.- The Distribution of Coronary and of Coronary Collateral Flow in Normal Hearts and After Chronic Coronary Occlusion.- Local Oxygen Tension and Blood Flow in the Normal and Chronic Ischemic Myocardium in the Anesthetized Dog.- Hemodynamic Evidence of the Development of Coronary Collateral Circulation in Conscious Dogs.- The Effect of Glyceryl Trinitrate on Coronary Collateral Flow — A Preliminary Report.- Discussion.- Section 4: Clinical Problems in the Coronary Circulation.- Relation of Coronary Events to Spasm of Coronary Arteries, Precariousness of Obstructive Lesions and Availability of Collateral Channels.- Vein Bypass Surgery for Ischemic Heart Disease Perspective — March, 1973.- Clinical Studies in the Selection of Patients for Coronary-Artery Surgery.- Coronary Artery Bypass.- Effects of Aorta-CoronaryBypass Grafts on Myocardial Contractile State: Response to Catecholamine Stress.- Coronary Artery Reperfusion: Early Effects on Coronary Hemodynamics.- Discussion.- Author Index.