Contemporary Management of Myeloproliferative Neoplasms

Myeloproliferative neoplasms (MPN) are a group of blood disorders related to leukaemia in which the body makes too many blood cells. MPN originates in the bone marrow - the soft tissue in the middle of the bones, where all the blood cells are made. In patients with MPN, normal blood cell production breaks down and the bone marrow becomes over-active and makes far too many blood cells. This can cause the blood to become thick. MPN can affect any of the blood cells (red, white and platelets) (Leukemia & Lymphona Research).

This book is a comprehensive guide to the diagnosis and management of MPN. Beginning with an introduction, the following chapters examine the diagnostic classification, epidemiology, clinical features and treatment of different types of MPN. A complete chapter is dedicated to hematopoietic stem cell transplant in myelofibrosis.

Edited by authoritative experts from Northwestern University Feinberg School of Medicine, Chicago, this useful reference is enhanced by detailed images, illustrations and tables.

Key points

• Comprehensive guide to diagnosis and treatment of myeloproliferative neoplasms
• Covers diagnostic classification, epidemiology, clinical features and treatment of different types of MPN
• Complete chapter dedicated to hematopoietic stem cell transplant
• Edited by recognised experts from Northwestern University Feinberg School of Medicine, Chicago

• Chapter 1: Diagnostic Criteria in the Myeloproliferative Neoplasms
• Chapter 2: Insights into Disease Pathogenesis of the Myeloproliferative Neoplasms
• Chapter 3: Thrombotic and Bleeding Complications in BCR-ABL Negative MPN
• Chapter 4: Essential Thrombocythemia
• Chapter 5: Polycythemia
• Chapter 6: Primary, Post-Pv And Post-Et Myelofibrosis: Clinical Features, Prognosis and Conventional Therapy
• Chapter 7: Hematopoietic Stem Cell Transplant in Myelofibrosis
• Chapter 8: Novel Therapies in the Classical Bcr-Abl Negative Myeloproliferative Neoplasms
• Chapter 9: Hypereosinophilic Syndromes
• Chapter 10: Mast Cell Diseases/Systemic Mastocytosis

Brady L Stein MD MHS
Assistant Professor

Brandon J McMahon MD
Assistant Professor

Both at Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA