Clinical Approach to Infection in the Compromised Host, Softcover reprint of the original 1st ed. 1988

"Infection in the Compromised Host" has become a classic chapter in textbooks devoted to infectious diseases and internal medicine. The numbers of compromised hosts are increasing in the era of modem medicine because of our expanded capabilities to deal with difficult diseases, especially neoplasms. As a consequence, microbiologic complications related to the intensive care administered to these patients are increasing as well. Under these circum­ stances, not only does the underlying illness create conditions favorable for the development of unusual infections, but often the therapy contributes to the acquisition of potential pathogens that turn into agents responsible for severe and frequently fatal disease. Granulocytopenia and immunosuppression have been the two key fac tors in predisposing patients with cancer and other serious diseases to severe bacterial infections. Colonization by hospital-acquired pathogens and breaks in the anatomic barriers-as a result of disease or medical intervention-have contributed to the high incidence of infectious diseases in these patients. Although there is some overlap between the types of infection in granulocytopenic and immunosuppressed hosts, each ofthese clinical entities has distinctive features thatjustify considering them separately, reserving the term immunocompromised hosts only when refer­ ring to patients who are predisposed to opportunistic infections. For about two decades, infections in granulocytopenic patients have attracted the atten­ tion of clinicians because they represent a model for the study of antimicrobial drugs in hosts deprived of an essential element of defense against bacterial infection, that is, an adequate number of normally functioning granulocytes.

1 Introduction.- 2 Epidemiology and Prevention of Infection in the Compromised Host.- 3 Defects in Host-Defense Mechanisms.- 4 Fever and Septicemia.- 5 Dermatologic Manifestations of Infection in the Compromised Host.- 6 Etiology and Management of the Compromised Patient with Fever and Pulmonary Infiltrates.- 7 Central Nervous System Infections in the Compromised Host.- 8 Fungal Infections in the Compromised Host.- 9 Mycobacterial and Nocardial Infections in the Compromised Host.- 10 Parasitic Diseases in the Compromised Host.- 11 Legionellosis in the Compromised Host.- 12 Viral Hepatitis in the Compromised Host.- 13 Herpes Group Virus Infections in the Compromised Host.- 14 Morbidity in Compromised Patients Due to Viruses Other Than Herpes Group and Hepatitis Viruses.- 15 Acquired Immunodeficiency Syndrome.- 16 Infections Complicating Congenital Immunodeficiency Syndromes.- 17 Diagnosis and Management of Infectious Disease Problems in the Child with Malignant Disease.- 18 Management of Infections in Leukemia and Lymphoma.- 19 Evaluation and Management of Infections in Patients with Collagen Vascular Disease.- 20 Infection Complicating Bone Marrow Transplantation.- 21 Infection in the Renal and Liver Transplant Patient.- 22 Infection in the Cardiac Transplant Patient.- 23 Surgical Aspects of Infection in the Compromised Host.