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Chesley's Hypertensive Disorders in Pregnancy (5th Ed.)

Langue : Anglais

Coordonnateurs : Taylor Robert N., Conrad Kirk P., Davidge Sandra T., Staff Anne Cathrine, Roberts James M.

Couverture de l’ouvrage Chesley's Hypertensive Disorders in Pregnancy

Leon Chesley?s Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley?s Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.

1. The Spectrum of Hypertensive Disorders in Pregnancy: Dr. Leon Chesley's Legacy

2. Epidemiology of Pregnancy-Related Hypertension

3. Genetic Factors in the Etiology of Preeclampsia/Eclampsia

4. Preconceptional and Periconceptional Pathways to Preeclampsia

5. Placentation and Placental Function in Normal and Preeclamptic Pregnancies

6. Unbiased Approaches for Addressing the Complexities of the Placenta's Role in the Preeclampsia Syndrome

7. The Immunology of Preeclampsia

8. Trophoblast Extracellular Vesicles in Preeclampsia

9. Angiogenesis and Preeclampsia

10. Vascular Endothelial Cell Dysfunction in Preeclampsia

11. Cardiovascular Alterations in Normal and Preeclamptic Pregnancy

12. Cardiometabolic Antecedents of Preeclampsia

13. Cerebrovascular Pathophysiology in Preeclampsia and Eclampsia

14. The Kidney in Normal Pregnancy and Preeclampsia

15. Salt, Aldosterone, and the Renin— Angiotensin System in Pregnancy

16. Platelets, Coagulation, and the Liver

17. Clinical Management and Antihypertensive Treatment of Hypertensive Disorders of Pregnancy

18. Prediction and Prevention of Preeclampsia

19. Long-Term Effects of Preeclampsia on Mothers and Offspring

20. Animal Models Used for Investigating Pathophysiology of Preeclampsia and Identifying Therapeutic Targets

21. Harmonization of Data and Biobanks for Preeclampsia Research

Robert N. Taylor, MD, PhD is Professor of Obstetrics and Gynecology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY. Previously, he was Professor of Obstetrics and Gynecology at The University of Utah, Wake Forest School of Medicine, Emory University, and Director of the Center for Reproductive Sciences at the University of California, San Francisco. Taylor received his undergraduate education at Stanford University and the combined MD-PhD at Baylor College of Medicine. He is a board-certified obstetrician-gynecologist and reproductive endocrinologist whose major research foci have included the role of placental angiogenesis and endothelial cell activation in preeclampsia, and the molecular actions of estrogen and progesterone on endometrial differentiation and neuroangiogenesis as they relate to endometriosis. Dr. Taylor served on executive committees of the American Board of Obstetrics and Gynecology, NIH Reproductive Scientist Development Program, the World Endometriosis Society and the California Institute for Regenerative Medicine.
Dr. Conrad has had a longstanding research interest in the hormonal, cellular and molecular mechanisms underlying maternal renal and systemic vasodilation, and increased arterial compliance during normal pregnancy with emphasis on the ovarian hormone, relaxin. More recently, he has been PD/PI of a NIH Program Project Grant designed to explore maternal pregnancy physiology and outcome in women conceiving through in vitro fertilization with focus on the contribution of the corpus luteum. Finally, Dr. Conrad has been exploring a role for dysregulated (pre)decidualization in the genesis of preeclampsia, and in the larger context of “endometrium spectrum disorders”. Dr. Conrad has combined preclinical and clinical research throughout his career to translate findings in animal models, tissues and cells to humans or vice versa. The main disease focus of his pregnancy research has been preecla
  • Summarizes the most relevant basic and clinical studies on hypertensive disorders of pregnancy, helping researchers and students stay up-to-date
  • Discusses the roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia
  • Widely acclaimed as an essential scholastic resource and enthusiastically endorsed by clinicians and scientists