Causes and Control of Colorectal Cancer, 1996 A Model for Cancer Prevention Developments in Oncology Series, Vol. 78

Causes and Control of Colorectal Cancer: A Model for Cancer Prevention is a ground- breaking monograph which takes a global, multidisciplinary approach to the causes, carcinogenesis and control of colorectal cancer. Over 1000 key studies were analyzed on colorectal cancer cause, carcinogenesis, primary prevention, early detection using modern screening techniques, and surveillance after tumor excision. All major research results are included up to the date of publication.
The key chapters include those on morphology, molecular biology and evolution of tumors, etiology chapters on heredity, diet, alcohol, smoking, physical activity, life stress and others, while major chapters in the area of colorectal cancer control are on primary prevention, early detection by screening and surveillance, and post-tumor excision surveillance. Important recommendations on primary prevention, screening and surveillance of colorectal tumors are made in keeping with the most current research data.
Causes and Control of Colorectal Cancer: A Model for Cancer Prevention takes colorectal cancer control into the 21st century, and suggests this to be the first cancer in which control will be largely achieved within the next generation, as a result of the unprecedented multidisciplinary research into causation, primary prevention, screening and surveillance over the past 30 years. The book also serves as a model for the control of other common malignancies, particularly cancers of the breast and prostate, the causes and prevention of which are less well understood.

Preface. 1. Principles of Cancer Causation. 2. Basic Structure and Function of the Large Bowel. 3. Molecular Evolution of Colorectal Neoplasms. 4. Morphology of Colorectal Neoplasia. 5. Heredity. 6. Diet. 7. Alcohol Consumption. 8. Smoking. 9. Physical Activity. 10. Cholecystectomy and Cholelithiasis. 11. Bowel Habit - Constipation, Diarrhea and Laxative Use. 12. Number of Children, Age at First Birth, Hormones. 13. Asbestos and Other Occupational Exposures. 14. Radiation. 15. Personality Factors and Life Stresses. 16. Religion and Religiousness. 17. Causes of Colorectal Neoplasia. A Model of Cancer Etiology. 18. Primary Prevention of Colorectal Tumors. 19. Principles of Cancer Screening and Surveillance. 20. Screening for Colorectal Tumors. 21. Surveillance After Colorectal Tumor Excision. 22. Control of Colorectal Cancer. Future Directions. Index.

Professor Gabriel A. Kune, MD, FRACS, FRCS(England), FACS, is a Gastrointestinal Surgeon, Professor of Surgery, University of Melbourne, Australia, and Consultant Surgeon, The Royal Melbourne Hospital. He is a past Hunterian Professor of the Royal College of Surgeons of England and has lectured extensively in the U.S.A., Europe, Australasia, Japan and South America.
In 1978 he established the large population-based Melbourne Colorectal Cancer Study, which examined all aspects of colorectal cancer incident, cause, prevention and survival, and is one of the most referenced studies in this field, the results of which have been widely published. Professor Kune is committed to the future successful control of colorectal cancer, and of the other common cancers also.