Cardiac electrophysiology.4th Ed.

Here's today's most authoritative and up-to-date information on basic and clinical electrophysiology. The 4th Edition covers everything from fundamental explanations of currents and channels, through the theoretical and experimental bases of cardiac electrical activity and arrhythmias, to current clinical understandings of arrhythmias and their treatment. It also features the most comprehensive updating and revision to date.

PART. STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION Chapter. Sodium Channels - Eduardo Marban Chapter. Cardiac Calcium Channels - Donald M. Bers Chapter. Voltage Regulated Potassium Channels - Gavin Y. Oudit, Rafael J. Ramirez and Peter H. Backx Chapter 4: Intracellular Signaling and Regulation of Cardiac Ion Channels - Anant Khositseth, David E. Clapham, and Michael J. Ackerman Chapter 5: Membrane Pumps and Exchangers - Larry. Hryshko Chapter 6: Sarcoplasmic Reticulum Ion Channels - Gerhard Meissner. Chapter 7: HCN Channels: From Genes to Function - Andreas Ludwig, Juliane Stieber, Sven Moosmang, Stefan Herrmann, Martin Biel, Franz Hofmann Chapter 8: Molecular Organization and Regulation of the Cardiac Gap Junction Channel Connexin43 - Mario Delmar , Heather S. Duffy, Paul Sorgen, Steven M. Taffet, David C. Spray PART. BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION Chapter 9: Biophysics of Normal and Abnormal Cardiac Sodium Channel Function - Jeffrey R. Balser Chapter 10: Gating of Cardiac Delayed Rectifier K+ Channels - Michael C. Sanguinetti and Martin Tristani-Firouzi Chapter 11: Heart Mechanoelectric Transduction - Frederick Sachs Chapter 12: Pacemaker Channels and Normal Automaticity - Dario DiFrancesco Chapter 13: Biophysical Properties of Inward Rectifier Potassium Channels - Justus Anumonwo Chapter 14: Homomeric and Heteromeric Gap Junctions - Volodya Hayrapetyan, Guoqiang Zhong, Agustín D. Martínez and Eric C. Beyer. Alonso P. Moreno PART. INTERMOLECULAR INTERACTIONS AND PHARMACOLOGY OF CARDIAC ION CHANNELS Chapter 15: Pharmacology of the Cardiac Na Channel - Jonathan C. Makielski, Bin Ye, Timothy J. Kamp, and Craig T. January Chapter 16: Pharmacology of L-type and T-type channels in the heart - Xiongwen Chen and Steven R. Houser Chapter 17: KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease - Sheila Carrol, Junko Kurokawa, and R.S. Kass Chapter 18: Drug-induced Channelopathies - Charlie Antzelevitch Chapter 19: Prospects for Pharmacological Targeting of Gap Junction Channels - Miduturu Srinivas, Heather Duffy, Mario Delmar, David C. Spray PART. ION CHANNELS AND CELLULAR ELECTROPHYSIOLOGY Chapter 20: Heterogeneous expression of Potassium channels - Jeanne M. Nerbonne Chapter 21: Gap Junction Distribution and Regulation in the Heart - Jeffrey E. Saffitz, Deborah L. Lerner, Kathryn A. Yamada Chapter 22: Cellular Mechanisms of Sinoatrial Activity - Itsuo Kodama, Haruo Honjo, Halina Dobrzynski, Mark R. Boyett Chapter 23: Mechanisms of AV nodal Excitability and Propagation - Igor R. Efimov and Vladimir P. Nikolsk Chapter 24: Intercellular Communication and Impulse Propagation - André G. Kléber Chapter 25: Cardiac tissue architecture Determines speed and safety of propagation - Stephan Rohr and Jan P. Kucera Chapter 26: Restitution, Repolarization and Alternans as Arrhythmogenic Substrate - Kenneth R. Laurita, Ph.D. and David S. Rosenbaum, M.D. Chapter 27: Mechanoelectric Transduction/Feedback: Prevalence and Pathophysiology - Max J. Lab PART. MODELS OF CARDIAC EXCITATION Chapter 28: Ionic mechanisms of cardiac electrical activity: A Theoretical Approach - Yoram Rudy Chapter 29: Two-dimensional propagation in cardiac muscle - Bradley Roth Chapter 30: Three-dimensional Propagation in Mathematical Models - Craig S. Henriquez, Joseph. Tranquello, David Weinstein, Edward Hsu, Christopher R. Johnson Chapter 31: Modeling Cardiac Defibrillation - Natalia Trayanova PART. NEURAL CONTROL OF CARDIAC ELECTRICAL ACTIVITY Chapter 32: Molecular and cellular bases of - and -adrenergic modulation of cardiac rhythm - Susan F. Steinberg, Richard B. Robinson, Michael R. Rosen Chapter 33: Nerve Sprouting and Cardiac Arrhythmias. - Lan S. Chen, Peng-Sheng Chen Chapter 34: Cholinergic Atrial Fibrillation - Leonid. Rosenshtraukh, Vadim. Fedorov, Oleg F. Sharifov PART. NONLINEAR DYNAMICS, SPIRALS AND HEART RHYTHMS Chapter 35: Theory of reentry - Marcel Wellner and Omer Berenfeld Chapter 36: Nonlinear Dynamics of Excitation and Propagation in Cardiac Muscle - Zhilin Qu, Alan Garfinkel Chapter 37: Rotors and Spiral Waves in Two Dimensions - Leslie Tung, Nenad Bursac, Felipe Aguel Chapter 38: Scroll waves in three dimensions - Arkady M. Pertsov PART. ARRHYTHMIA MECHANISMS Chapter 39: Electrophysiology of the Pulmonary Veins: Mechanisms of initiation of atrial fibrillation - Jeffrey E. Olgin Chapter 40: Mechanisms of Maintenance of Atrial Fibrillation - Omer Berenfeld Chapter 41: Electrical Remodeling and Chronic Atrial Fibrillation - David R. VanWagoner Chapter 42: Mechanisms of Initiation of Ventricular Tachyarrhythmias - Jiashin Wu, Jianyi Wu, and Douglas P. Zipes Chapter 43: Dynamics and Molecular Mechanisms of Ventricular Fibrillation in Normal Hearts - José Jalife Chapter 44: Mechanisms of ventricular fibrillation in the ischemic heart - Alexey Zaitsev Chapter 45: Cellular mechanisms of defibrillation - Vladimir G. Fast Chapter 46: Global mechanisms of defibrillation - Richard A.Gray Chapter 47: Defibrillation Waveforms - Raymond E. Ideker, Joan Huang, Gregory Walcott PART. MOLECULAR GENETICS AND PHARMACOGENOMICS Chapter 48: Mouse Models of Cardiac Arrhythmias - Barry London Chapter 49: Human molecular Genetics and the Heart - Jeffrey A. Towbin, Neil Bowles Chapter 50: Genetics of Long QT, Brugada and other channelopathies. - Silvia G. Priori, Ilaria Rivolta, Carlo Napolitano Chapter 51: Pharmacogenomics of Cardiac Arrhythmias and Impact on Drug Therapy - Dan M. Roden PART. CLINICAL ARRHYTHMIAS MECHANISMS, FEATURES AND MANAGEMENT SUPRAVENTRICULAR ARRHYTHMIAS Chapter 52: Sinus rhythm abnormalities - David J. Callans and David J. Lin Chapter 53: Atrioventricular Block And Atrioventricular Dissociation - David Schwartzman Chapter 54: Atrial Flutter: Mechanisms, Clinical Features and Management - Albert L. Waldo Chapter 55: Atrial tachycardia - Kenneth A. Ellenbogen and Mark A. Wood Chapter 56: Atrial fibrillation - Stanley Nattel and Joachim R. Ehrlich Chapter 57: Junctional Rhythms and Tachycardia - Hakan Oral and S. Adam Strickberger Chapter 58: Atrioventricular reentry and variants - Bradley P. Knight and Fred Morady Chapter 59: Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Reentrant Circuits - Deborah Lockwood, Kenichiro Otomo, Zulu Wang, Sara Forresti, Hiroshi Nakagawa, Karen Beckman, Benjamin J Sc

Clinical Electrophysiologists, Cardiologists, Electrophysiology Researchers