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Biomarkers in Bone Disease, 1st ed. 2017 Biomarkers in Disease: Methods, Discoveries and Applications Series

Langue : Anglais

Coordonnateurs : Patel Vinood B., Preedy Victor R.

Couverture de l’ouvrage Biomarkers in Bone Disease
In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.
Serum uric acid and biomarkers of lumbar spine bone mineral density.- Use of alkaline phosphatase (ALP) activity and disease severity to determine secular changes in bone disease as applied to Paget's disease of the bone.- Bone Turnover and Spinal Cord Injury.- Bone-related proteins as markers in vascular remodelling.-  Serum Sclerostin as Biomarker in Osteogenesis Imperfecta.- Parathyroid Hormone (PTH) assays and applications to bone disease: Overview on methodology.- Registered microcomputed tomography data as a four dimensional imaging biomarker of bone formation and resorption.- Use of bone biomarkers after weight loss: Example of bariatric surgery.- Adiponectin as biomarker of osteoporosis.- Effect of statins on bone turnover markers.- Chitinases as biomarkers in bone studies.- Hormone relaxin as biomarker for bone health and disease.- Panoramic radiomorphometric indices of mandible: Biomarker for osteoporosis.- Hip Fracture Risk is Strongly Related to Circulating Levels of the Advanced Glycation End-product Carboxy-Methyl Lysine (CML).- Effects of glucose on bone markers: Overview of current knowledge with focus on diabetes, glucose, and bone markers.- Traditional medicine and use of bone biomarkers.- Osteosarcoma Biomarkers discovery using "omics" approaches.- Creatine kinase as biomarker in osteogenesis imperfecta.- Ameloblastin as biomarker of bone.- Biomarker genes in autosomal dominant osteopetrosis type II (ADO II).- Bone markers in Rett syndrome.- Bone Specific Alkaline Phosphatase and Exercise.- Bone turnover markers and glucocorticoid treatments.- Overview of biochemical markers of bone metabolism.- Biomarkers of natural radionuclides in bone and teeth.- Bone markers throughout sexual development: epidemiological significance and population-based findings.- Parathyroid hormone (PTH) and the relationship between PTH and bone health: structure, physiology, actions, and ethnicity.- Quantitative ultrasound as a biomarker tool in newborn infants for bone.- Bone biomarkers in gestational hypertension.- Bone biomarkers in intrauterine growth restriction.- Raman spectroscopy as a biomarker-investigative tool in bone metabolism.- Pentosidine as a biomarker for poor bone quality and elevated fracture risk.- Spine bone texture and the trabecular bone score (TBS).- Bone biomarkers in HIV.- Bone Biomarkers Related to Osteoarthritis.- Dietary Soy Phytoestrogens and Biomarkers of Osteoporosis.- Utilisation and reference values of osteocalcin and procollagen type 1 n-propeptide.- Analysis of integrin alpha2beta1 (a2b1) expression as a biomarker of skeletal metastasis.- Circulating Sclerostin in Bone Sclerosing Disorders.- Pentraxin 3 as a bone biomarker.- Sirtuins as markers of bone disease: a focus on osteoarthritis and osteoporosis.- Tartarate resistant acid phosphatase as a biomarker of bone remodeling. 
Professor Victor R. Preedy is a senior faculty member of King's College London (Professor of Nutritional Biochemistry) and King's College Hospital (Professor of Clinical Biochemistry). He is attached to both the Diabetes and Nutritional Sciences Division and the Department of Nutrition and Dietetics. He is also Director of the Genomics Centre and a member of the School of Medicine. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1993 he gained his second doctoral degree, for his outstanding contribution to protein metabolism in health and disease. He has received membership and fellowship of a number of academic and professional bodies in the UK, including the Royal College of Pathologists, the Royal Institute of Public Health, and the Royal Society of Chemistry. Professor Preedy has published over 570 articles, which includes 165 peer-reviewed manuscripts based on original research, 100 reviews, and over 50 books and book volumes.
Bridges intellectual divides and useful for student nurses and advanced practitioners
Written by experts
Each chapter has an abstract, key facts, definition of words and terms, potential applications to other diseases conditions or prognosis, summary points
Fills a much needed gap to have a one volume “one-stop-shopping” synopsis of the scientific basis of biomarker discovery or application

Date de parution :

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 685,74 €

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Date de parution :

Ouvrage de 1185 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 369,24 €

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