Biological and Hormonal Therapies of Cancer, 1998 Cancer Treatment and Research Series, Vol. 94

This volume, Biological and Hormonal Therapies of Cancer, which is part of the series Cancer Treatment and Research, presents selected new information concerning biologic and hormonal therapy of cancer. We have attempted to provide the reader with topics of major interest in a timely fashion. There is renewed interest in biologic therapy of cancer. Two chapters review the role of interferon in the hematologic malignancies and in solid tumors. Vaccine therapies have come to the forefront of cancer therapy re­ cently, and two chapters approach different strategies of vaccine therapies; one reviews the cellular vaccine therapies and another the anti-idiotype ap­ proach. The hormonal therapy chapters focus on current uses of endocrine therapy in endometrial, breast, and prostate cancer. In addition, hormonal strategies for the prevention of breast cancer and endometrial cancer, including excit­ ing information relating to phytochemicals, are presented. The effects of tamoxifen on endometrium is a topic of major interest and is discussed in detail. Finally, there is a chapter on estrogen receptor expression and regula­ tion in human breast cancer. These chapters are all written by experts in the field and contain timely and relevant information of interest to laboratory and clinical scientists and practitioners alike. Biologic and endocrine therapies represent major areas of cancer research interest. The advent of newer biologic therapies, including new antibody­ targeted treatments, and the use of biologics as tumor modulators to enhance the effects of other treatment regimens is an exploding avenue of research.

1. Interferon therapy of hematologic malignancies.- 2. Interferon Use in Solid Tumors.- 3. Cellular vaccine therapies for cancer.- 4. Anti-idiotype antibody vaccine therapies of cancer.- 5. Endocrine therapy of prostate cancer.- 6. Endocrine therapy of endometrial cancer.- 7. Phytochemicals for the prevention of breast and endometrial cancer.- 8. Hormonal strategies for the prevention of breast cancer.- 9. Ovarian ablation as adjuvant therapy for early-stage breast cancer.- 10. The duration of adjuvant tamoxifen therapy.- 11. Tamoxifen and the endometrium.- 12. Hormone replacement therapy and nonhormonal control of menopausal symptoms in breast cancer survivors.- 13. Endocrine therapy in metastatic breast cancer.- 14. The regulation of estrogen receptor expression and function in human breast cancer.

This volume presents selected new information concerning biological and hormonal therapies of cancer. Chapters on biologic therapy contain information on the role of interferon in the hematologic malignancies in solid tumors, vaccine therapies, cellular vaccine therapies, anti-idiotype approach and interleukin-2 in the therapy of solid tumors. Chapters on hormonal therapy contain information on current uses of endocrine therapy in endometrial, breast and prostate cancer, hormonal strategies for the prevention of breast and endometrial cancer including information related to phytochemicals, the effects of tamoxifen on endometrium and estrogen receptor expression and regulation in human breast cancer. Biologic and endocrine therapy represent major areas of cancer research interest. The adve