Biliary Disease, Softcover reprint of the original 1st ed. 2017 From Science to Clinic

David H. Adams, MD, FRCP, FMedSci is the Pro-Vice-Chancellor, Head of College of Medical and Dental Sciences and Dean of Medicine at the University of Birmingham, UK, as well as Professor of Hepatology and Honorary Consultant Hepatologist. He is an international leader in inflammatory liver disease and immune mechanisms of liver injury and has been at the forefront of developments in liver immunology over the last 20 years.  He has published more than 250 papers and has attracted significant grant income nationally and internationally. His clinical interests are transplant hepatology and autoimmune liver disease.  He has played major leadership roles nationally and internationally.  He has a particular interest in clinical academic careers and chairs the AMS Mentoring working group and has been a member of fellowship panels at MRC, Wellcome Trust and Core and INSERM (France). Laboratory research interests are focused on mechanisms of immune-mediated liverdisease. He was made a Fellow of the Academy of Medical Sciences in 2000 and an NIHR senior investigator in 2013.  He has a long-standing interest in understanding how leukocyte-endothelial interactions regulate the development and persistence of chronic inflammation and fibrosis in liver disease and how specific micro-environmental signals determine the positioning, activation and survival of effector cells within the liver. Based on this knowledge his laboratory demonstrated the role of specific adhesion molecules and chemokines in liver disease and helped to define the function of novel molecules including vascular adhesion protein-1.  His laboratory are now using their knowledge of the molecular mechanisms that regulate leukocyte trafficking to the liver to develop immune and cellular therapies for liver disease through the facilities provided by the Birmingham NIHR Liver BRU.

Gideon M. Hirschfield, MA, MB, BChir, FRCP, PhD is a Professor and Honorary Co