Bile acid biology and its therapeutic implications, (Falk symposium, Vol. 141)

This book is the proceedings of the 18th International Bile Acid Meeting, held as the Falk Symposium 141 in Stockholm, Sweden, on June 18?19, 2004. The International Bile Acid Meetings have become some of the most important meetings in the bile acid field worldwide since Herbert Falk decided to sponsor these Symposia in biannual sequence in 1970. The 17 International Bile Acid Meetings in the past have been a great stimulus for new ideas and methods as well as the development of therapeutic applications of bile acids. They have always been a forum where basic scientists and clinicians interact. Many novel results of bile acid research were first presented at these meetings. The meeting in Stockholm again attracted a large number of basic and clinical scientists interested in bile acid and biliary research from all over the world. Knowledge about the regulation of bile acid synthesis, bile acid transport and enterohepatic circulation in health and in disease has increased considerably during recent years. Accordingly, bile acid research is alive as ever. A new chapter of bile acid research was opened by the finding that bile acids are ligands of nuclear receptors which regulate synthesis, metabolism and transport of bile acids and steroids. A large part of the book is devoted to these topics. The 18th International Bile Acid Meeting was again a truly interdisciplinary symposium at the highest scientific level. Its participants enjoyed hearing the latest reports on bile acid research in the city where so many seminal studies on bile acids were performed. It is hoped that the readers of this book will share the enjoyment.

Section I: Synthesis And Metabolism Of Bile Acids.1 Multifunctional roles of bile acid biosynthetic enzymes and the isolation of a new vitamin D 25-hydroxylase, D.W. Russell, J.B. Cheng. 2 Studies on biosynthetic pathways to bile acids in human liver cells, M. Axelson, B. Mörk, K. Garmark, J. Shoda, G.T. Everson, J. Sjövall. 3 Role of CYP3A4 as a cholesterol and bile acid metabolizing enzyme, K. Bodin, U. Diczfalusy. 4 New insights into bile acid amidation, M.C. Hunt, E. O'Shea, K. Solaas, B. Frode Kase, S.E.H. Alexson. 5 Mechanisms of bile acid inhibition of bile acid synthesis, J.Y.L. Chiang, T. Li, B. Spalding-Yoder, S. Del Signore. 6 The farnesoid X receptor controls gene expression in a ligand-and promoter-selective fashion, J. Cui, J.-L. Lew, A. Zhao, L. Huang, S.D. Wright. 7 Regulation of bile acid biosynthesis by cell signalling pathways, P.B. Hylemon, S. Gupta, R. Natarajan, P. Dent. 8 Feedback regulation of human bile acid synthesis, E.C.S. Ellis, M. Axelson, A. Abrahamsson, G. Eggertsen, B.-G. Ericzon, I. Björkhem, C.A. Einarsson. 9 On the role of oxysterols in regulation of cholesterol homeostasis by nuclear receptors, S. Meaney, I. Björkhem. Section II: Transport Of Bile Acids And Lipids. 10 Bile acid transport in Spgp (Bsep) knockout mice, P. Lam, R. Wang, V. Ling. 11 Bile salt and glutathione coefflux mediated by multidrug resistance protein MRP4 (ABCC4), a basolateral transporter of the hepatocyte, M. Rius, A.T. Nies, A.F. Hofmann, D. Keppler. 12 The role of farnesoid X receptor in regulating bile salt transport and synthesis, J.J. Eloranta, G.A. Kullak-Ublick. 13 Gender-specific expression of liver organic anion transporters, D. Rost, K. Kopplow, S. Gehrke, A. Stiehl, D. Mayer. 14 Molecular mechanisms of intestinal bile acid transport, A.L. Craddock, J.H. Haywood, M.L. Hubbert, P.A. Dawson. 15 Adaptive regulation of bile salt transporters in cholestasis ? the role of MRP, W.S. Chen, A. Bohan, G. Denk, C. Soroka, L. Denson, J.L. Boyer. 16 Adaptive hepatobiliary transporter regulation by ursodeoxycholic acid, M. Trauner, P. Fickert, E. Halilbasic, M. Wagner, G. Zollner. 17 Molecular mechanism of biliary lipid secretion, A.K. Groen, R.P.J. Oude Elferink. 18 Haplotype analysis of hepatobiliary ABC transporter genes in cholecystolithiasis, F. Lammert, H.E. Wasmuth, R. Schirin-Sokhan, N. Rhabar-Tabrizi, H.-U. Marschall, S. Matern. 19 Molecular elucidation of intestinal cholesterol absorption, W. Kramer, F. Girbig, D. Corsiero, A. Pfenninger, W. Frick, G. Jähne. Section III: Biological And Pharmacological Effects Of Bile Acids. 20 Actions of the bile acid receptor FXR, S. Kliewer. 21 Activation of MRP2 transport by ursodeoxycholic acid and its amidates, M. Vore, P. Gerk. 22 Role of mitogen-activated protein kinases in tauroursodeoxycholic acid-induced bile secretion in cholestatic rat liver, S. Hohenester, G.U. Denk, R. Wimmer, C. Rust, U. Beuers. 23 Bile acids and CD95 activation, D. Häussinger, A. Höngen, S. Becker, R. Reinehr. 24 Tauroursodeoxycholic acid, a bile acid with in-vivo antiapoptotic and neuroprotective properties, C.M.P. Rodrigues, C.J. Steer.Section IV: Bile Acids As Therapeutic Agents. 25 Clinical presentation and treatment of familial unconjugated hypercholanaemia, A.K. Batta, G. Salen, D.H. Morton, V.E.H. Carlton, L.N. Bull, B.L. Shneider. 26 Comprehensive study of the effects of rifampicin and ursodeoxycholic acid on genes and proteins involved in regulation, transport and detoxification of biliary compounds in gallstone patients, H.-U. Marschall, M. Wagner, G. Zollner, P. Fickert, J. Gumhold, D. Silbert, U. Diczfalusy, L. Benthin, R. Grundström, U. Gustafsson, S. Sahlin, C. Einarsson, M. Trauner. 27 Dose effect of ursodeoxycholic acid used in the treatment of primary biliary cirrhosis and primary sclerosing cholangitis, K.D. Lindor. 28 Safety and efficacy of budesonide combined with ursodeoxycholic acid in the treatment of