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Associative Memory Cells: Basic Units of Memory Trace, 1st ed. 2019

Langue : Anglais

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This book provides with comprehensive diagrams about associative memory cells and their working principles that may be applied to associative memories and memory-relevant cognitions. It also presents author's personal perspectives about pathology and therapeutic strategies for memory deficits in patients suffering from neurological diseases and psychiatric disorders. Associative learning is a common approach to acquire multiple associated signals including knowledge, experiences and skills from nature environments or social interaction. The revelation of cellular and molecular mechanism underlying associative memory is important for us to understand the principles of memory formation and memory-relevant behaviors as well as to develop the therapeutic strategies that enhance memory capacity in health individuals and improve memory deficit in patients suffering from neurological disease and psychiatric disorders. Although a series of hypotheses about neural substrates for associative memory has been proposed, numerous questions still need to be addressed, especially basic units and their working principle in engram circuit specifically for various memory patterns. This book summarizes the developments about associative memory cells from historical and current literatures. It will serve as a valuable source for neuroscientists, psychologists and students to get an overview of this field.

History in the study of learning and memory.- Patterns of learning and memory.- Cellular and molecular changes in associative memory.- Associative memory cells in memory trace.- Plasticity of associative memory cells.- Working principles of associative memory cells.- Modulation of associative memory cells by neurotransmitters and hormones.- Genetics and epigenetics of associative memory cells.- Animal models of associative learning and memory.- The impact of associative memory cells on physiology and pathology.

Wang Jin-Hui has received PhD from Shanghai Institute of Physiology, Chinese Academy of Sciences. After postdoctoral training in State University of New York and University of Texas, Wang has joined to University of Kansas as tenure-track assistant professor. Subsequently, Wang is appointed by Chinese Academy of Sciences as a distinguished professor. After being an independent researcher, Wang has found working principles of neurons and synapses about the conversion of inactive into active synapses, the conversion of irregular to regular transmission pattern at unitary synapse, homeostatic plasticity among subcellular compartments, spike amplification at axons as well as the functional compatibility between axonal branches and their postsynaptic partners. In terms of cellular architecture for learning and memory, Wang’s group has discovered and identified associative memory cells as basic units in memory trace.

Discussing the molecular and cellular mechanisms and regulations of associative memory

Providing with comprehensive views about associative memory cells and their networks

Issuing perspectives about pathology and therapeutic strategies of memory deficits

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15.5x23.5 cm

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