Antifungal Therapy

This book provides a comprehensive, up-to-date overview of the pertinent issues pertaining to antifungal treatment. Divided into four interrelated sections for a cohesive discussion covers:

• history of antifungals from the discovery of the polyenes to the echinocandins
• antifungal susceptibility methods
• patient management
• animal models in drug development
• therapeutic strategies
• pharmacokinetic and pharmacogenomics
• trends in resistance

General Introduction to the Management Issues
History of Antifungals
Ali Abdul Lattif and Kim Swindell
Epidemiology of Fungal Infections: What, Where, and When
Sylvia F. Costa and Barbara D. Alexander
Experimental Animal Models of Invasive Fungal Infections
Yoshifumi Imamura and Mahmoud A. Ghannoum
Antifungal Drug Resistance: Significance and Mechanisms
Pranab K. Mukherjee and Mingyue Wang
Antifungal Prophylaxis: An Ounce of Prevention isWorth a Pound of Cure
Aimee K. Zaas
Preemptive Antifungal Therapy: Do Diagnostics Help?
Kimberly E. Hanson
The Immune Response to Fungal Challenge
Jeffery J. Auletta
Immunomodulators: What is the Evidence for Use in Mycoses?
J. Andrew Alspaugh
Fungal Biofilms and Catheter-Associated Infections
Jyotsna Chandra and Mahmoud A. Ghannoum

Antifungal Drug Classes
Polyenes for Prevention and Treatment of Invasive Fungal Infections
Richard H. Drew
Flucytosine
Richard H. Drew
Pharmacology of Azole Antifungal Agents
Elizabeth S. Dodds Ashley
Echinocandins for Prevention and Treatment of Invasive Fungal Infections
Melissa D. Johnson and John Mohr
Novel Administrations of Antifungals
Richard H. Drew

Management of Specific Mycoses
Dermatophytosis
Susan A. Keiler and Mahmoud A. Ghannoum
Invasive Candidiasis
Rana Traboulsi and Mahmoud A. Ghannoum
Invasive Aspergillosis
Rana Traboulsi
Management of Cryptococcosis
John R. Perfect
Management of Endemic Mycoses
John R. Perfect
Human Hyalohyphomycoses: A Review of Human Infections Due to Acremonium spp., Paecilomyces spp., Penicillium spp., and Scopulariopsis spp.
Mahmoud A. Ghannoum
Management of Phaeohyphomycosis
John R. Perfect
Pneumocystis
Kim Swindell
Management of Zygomycosis
John R. Perfect

The Paradigm of Risk Group/Infection Site Assessments
Antifungal Management in Risk Groups: Transplant Recipients
Sylvia F. Costa and Barbara D. Alexander
Prophylaxis and Treatment of Invasive Fungal Infections in Neutropenic Cancer and Hematopoietic Stem Cell Transplant Patients
Selmin A. Ataergin and Hillard M. Lazarus
Infants: Yeasts Are Beasts in Early Life
P. Brian Smith and Daniel K. Benjamin, Jr.
Newer Antifungal Agents in Pediatrics
Christina Henn and William J. Steinbach
Fungal Infections in Burn Patients
Jose A. Vazquez
Allergic Bronchopulmonary Aspergillosis
Rana Traboulsi
Fungal Infections of the Genitourinary Tract
Rana Traboulsi and Souha Kanj