Advances in the Neuroscience of Addiction Frontiers in Neuroscience Series
Coordonnateurs : Kuhn Cynthia M., Koob George F.
Understanding the phenomenon of long-lasting vulnerability to addiction is essential to developing successful treatments. Written by an international team of authorities in their respective fields, Advances in the Neuroscience of Addiction provides an excellent overview of the available and emerging approaches used to investigate the biologic mechanisms of drug addiction. It also delineates the promising research discoveries being made in relapse prevention.
The book begins with current animal models of addiction, which mimic the state of humans entering treatment: recently-abstinent animals that receive common triggers for relapse (classical conditioning, stress, and neuroadaptive dysregulation). Coverage then shifts to the use of electrophysiologic approaches, which enable researchers to characterize the discharge patterns of single neurons during drug self-administration. After exploring advances in voltammetry and enzyme-linked biosensors for measuring glutamate, the book discusses the theoretical background and results of neuroimaging studies related to neuronal networks that are activated by drug-specific cues. It then describes modern genetic approaches to manipulate target proteins that influence addictive behavior.
The book rounds out its coverage by illustrating how a neuroeconomic approach can inform studies of reward processing in general and addiction in particular. It is a comprehensive introduction to the methodologies of the field for students and beginning researchers and an essential reference source for established investigators.
Advances in Animal Models of Relapse for Addiction Research. Application of Chronic Extracellular Recording Method to Studies of Cocaine Self-Administration: Method and Progress. Neurochemistry of Addiction: Monitoring Essential Neurotransmitters of Addiction. Alcohol Craving and Relapse Prediction: Imaging Studies. Integrating Behavioral and Molecular Approaches in Mouse: Self-Administration Studies. Neuroeconomics: Implications for Understanding the Neurobiology of Addiction.
Cynthia M. Kuhn, Duke University Medical Center, Durham, North Carolina, USA
George F. Koob, The Scripps Research Institute, La Jolla, California, USA
Date de parution : 09-2017
15.6x23.4 cm
Date de parution : 04-2010
Ouvrage de 222 p.
15.6x23.4 cm
Thèmes d’Advances in the Neuroscience of Addiction :
Mots-clés :
Cocaine Self-administration; Drug Self-administration; cocaine; Ventral Striatum; self-administration; 6J Genes; ventral; RST; striatum; D2 Receptor Availability; conditioned; NAc Neuron; stimuli; FSCV; nucleus; Self-administration Session; accumbens; Conditioned Reinforcer; alcohol; Drug Seeking Behavior; cues; D2 Receptor; Response Contingent Presentation; Brain Activation; Drug Seeking Behaviors; Firing Patterns; Average Firing Rate; LIF; Carbon Fiber Electrode; Dat Knockout Mouse; Alcohol Craving; Alcohol Dependent Patients; Dopamine D2 Receptor; Lever Press; Average Firing