Adenosine Receptors in Neurodegenerative Diseases
Coordonnateurs : Blum David, Lopes Luisa V.
Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field.
Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience.
Section I. Physiology 1. Physiology: Adenosine receptor biology in the CNS Michael Freissmuth and Karl-Norbert Klotz 2. Physiology: Adenosine signaling throughout development Stefania Zappettini and Christophe Bernard 3. Physiology: Influence of adenosine on synaptic excitability Detlev Boison, Raquel B. Dias, Traci Plumb, Sofia Cristóvão-Ferreira and Ana Sebastiao 4. Physiology: Regulation of synaptic transmission by adenosine at the neuromuscular junction Paula Pousinha and Joaquim A. Ribeiro 5. Physiology: Gene-regulation of adenosine A2A receptors in the central nervous system Marta Barrachina, Chien-Yu Lin and Yijuang Chern
Section II. Pathology 6. Pathology: Sleep, adenosine, and neurodegeneration Theresa Bjorness and Robert W. Greene 7. Pathology: neuronal vs glial cell contribution to adenosine A2A receptor-induced neurodegeneration Antonella Ferrante, Maria Teresa Tebano, Alberto Martire, Maria Rosaria Domenici and Patrizia Popoli 8. Pathology: Adenosine and oxygen/glucose deprivation in the brain Felicita Pedata, Ilaria Dettori, Irene Fusco, Elisabetta Coppi, Anna Maria Pugliese and Alessia Melani 9. Pathology: Adenosine receptors and memory disorders Alexandre de Mendonca, David Blum and Jonathan D. Geiger 10. Pathology: Control of motor function by adenosine A2A receptors in Parkinson and Huntington disease Annalisa Pinna, Jadwiga Wardas, Maria Rosaria Domenici, Patrizia Popoli, Giovanni Cossu and Micaela Morelli 11. Pathology: Adenosine receptors oligomers in Parkinson disease Victor Fernández-Dueñas and Francisco Ciruela 12. Pathology: Adenosine control of striatal function – implications for the treatment of apathy in basal ganglia disorders Sergi Ferré
Advanced graduate students, researchers, clinicians, and industry scientists in the fields of neurodegeneration, neuroscience, neurology, and neuropharmacology
Luísa V. Lopes is a Group leader@iMM Lisboa, Portugal. Her current work focuses on understanding the mechanisms inducing the "early-aging" of the cognitive function. The team has extensively provided evidence for an important contribution of adenosine receptors in pathophysiological context, and their impact in noxious brain conditions such as stress, aging and neurodegeneration, being awarded by FEBS, FENS and EMBO. Luisa graduated in Lisbon in 1998 in Biochemistry and then pursued a PhD in Neuro
- Comprehensive reference that details adenosine receptors in neurodegenerative disorders, with details on brain function and possible therapeutics
- Gives insights on how these receptors modulate the neurodegenerative outcomes in different disorders
- Edited by two of the leading researchers in the field regarding adenosine role in the brain in aging and neurodegenerative conditions
Date de parution : 03-2017
Ouvrage de 280 p.
15x22.8 cm