Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents, 1st ed. 2018 JSS Research Series in Statistics Series
Auteurs : Hirakawa Akihiro, Sato Hiroyuki, Daimon Takashi, Matsui Shigeyuki
1. Introduction.- 2. Phase I Trials for Drug Development in Oncology.- 3. A Summary of Dose.- Finding Methods in Standard Phase I Trials .- 4. Phase I Trials for Combination of Two Agents.- 5. Phase I Trials for Joint Assessment of Both Efficacy and Toxicity.- 6. Additional Topics on Adaptive Dose.- Finding Methods.
- Takashi Daimon, Division of Biostatistics, Hyogo College of Medicine
- Hiroyuki Satom, Biostatistics Group, Center for Product Evaluation, Pharmaceuticals and Medical Devices Agency
- Shigeyuki Matsui, Department of Biostatistics, Nagoya University Graduate School of Medicine
Focuses on the two advanced areas of adaptive model-based dose-finding methods for phase I trials with multiple drugs/outcomes in oncology and other fields
Provides software implementations to facilitate planning of phase I trials using these methods in practice
Serves as an excellent handbook for design and analysis of early-phase dose-finding trials, for graduate students and postdoctoral fellows in biostatistics, statisticians, and clinical investigators
Date de parution : 02-2018
Ouvrage de 89 p.
15.5x23.5 cm