Confidence Intervals for Discrete Data in Clinical Research Chapman & Hall/CRC Biostatistics Series
Auteurs : Pradhan Vivek, Gangopadhyay Ashis, Menon Sandeep M., Basu Cynthia, Banerjee Tathagata
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Confidence Intervals for Discrete Data in Clinical Research is designed as a toolbox for biomedical researchers. Analysis of discrete data is one of the most used yet vexing areas in clinical research. The array of methodologies available in the literature to address the inferential questions for binomial and multinomial data can be a double-edged sword. On the one hand, these methods open a rich avenue of exploration of data; on the other, the wide-ranging and competing methodologies potentially lead to conflicting inferences, adding to researchers' confusion and frustration and also leading to reporting bias. This book addresses the problems that many practitioners experience in choosing and implementing fit for purpose data analysis methods to answer critical inferential questions for binomial and count data.
The book is an outgrowth of the authors' collective experience in biomedical research and provides an excellent overview of inferential questions of interest for binomial proportions and rates based on count data, and reviews various solutions to these problems available in the literature. Each chapter discusses the strengths and weaknesses of the methods and suggests practical recommendations. The book's primary focus is on applications in clinical research, and the goal is to provide direct benefit to the users involved in the biomedical field.
1. A Brief Review of Statistical Inference. 2. Are We Slaves to the P-Value: The ASA's Statement on P-Value. 3. One Binomial Proportion. 4. Two Independent Binomials: Difference of Proportions. 5. Two Independent Binomials: Ratio of Proportions. 6. Paired Binomials: Difference of Proportions. 7. One Sample Rates for Count Data.
Vivek Pradhan has been working in the industry for more than twenty years. Currently he is a senior director in statistics in Early Clinical Development of Pfizer where he is responsible for managing all the statistical aspects of drug development from pre-clinical to Phase IIB trials. He has been publishing methodological papers on discrete data, and a regular invited speaker in several industry conferences and forums.
Ashis K Gangopadhyay is an Associate Professor of Statistics in the Department of Mathematics and Statistics at Boston University. His research areas include predictive modeling in clinical research, nonparametric and semiparametric methods, and analysis of financial data. He has authored numerous extensively cited research papers and mentored many Ph.D. students.
Sandeep Menon is Senior Vice President and the Head of Early Clinical Development at Pfizer Inc. and holds Adjunct faculty positions at Boston University School of Public Health, Tufts University School of Medicine, and the Indian Institute of Management. At Pfizer, he is in the Worldwide Research, Development and Medical Leadership Team and leads a multi-functional global team. Before joining the industry, he practiced medicine in Mumbai and was Resident Medical Officer. Sandeep is an elected fellow of the American Statistical Association (ASA), awarded the Young Scientist Award by the International Indian Statistical Association, the Statistical Excellence Award in Pharmaceutical Industry by Royal Statistical Society, UK and recently awarded the Distinguished Alumni Award by the Department of Biostatistics at Boston University School of Public Health. He received his medical degree from Karnataka University, India, and later completed his Masters in Epidemiology and Biostatistics and Ph.D. in Biostatistics at Boston University and research Assistantship at Harvard Clinical Research Institute. He has published more than 50 scientific original
Date de parution : 01-2024
15.6x23.4 cm
Date de parution : 11-2021
15.6x23.4 cm
Thèmes de Confidence Intervals for Discrete Data in Clinical Research :
Mots-clés :
SAS Code; Coverage Probability; confidence interval; HPD Interval; clinical trials; Wald Interval; bootstrapping confidence intervals; nonparametric methods continuous data; SAS Output; count data; SAS's Proc Freq; binomial data; StatXact PROCs; PROC FREQ; Credible Intervals; Proc MCMC; Independent Binomial Proportions; Nominal Coverage Level; Profile Likelihood; ASA Statement; Posterior Distribution; Likelihood Ratio Interval; Simulated Coverage Probabilities; CP Method; MCMC Sample; Wald CI; PROC GENMOD; ZINB Model; Mid-P Interval; Asymptotic Intervals