Section 1. Pharmacology and Mechanisms
Chapter 1. Chemistry, Pharmacodynamics, and Pharmacokinetics of NSAIDs
Sara Calatayud and Juan Vicente Esplugues
Chapter 2. Principles, Mechanisms of Action, and Future Prospects of Anti-Inflammatory Drugs
Bibiana Rius and Joan Clària
Section 2. Clinical Effects and Drug Safety
Chapter 3. Efficacy of NSAIDs in the Treatment of Rheumatic Diseases
Marc C. Hochberg and Lee S. Simon
Chapter 4. Adverse Effects of NSAIDs in the Gastrointestinal Tract: Risk Factors of Gastrointestinal Toxicity with NSAIDs
Sunny H. Wong and Francis K.L. Chan
Chapter 5. Adverse Effects of NSAIDs on the Cardiovascular System
Carmelo Scarpignato and Corrado Blandizzi
Chapter 6. Safe Prescription of NSAIDs in Clinical Practice
Mohammad Yaghoobi and Richard H. Hunt
Section 3. Aspirin
Chapter 7. NSAIDS and Aspirin: Recent Advances and Implications for Clinical Management
Karsten Schrör and Michael Voelker
Chapter 8. Non-Prescription Analgesic Anti-inflammatory Drugs: Efficacy and Safety
Denis M. McCarthy
Chapter 9. Low-Dose Aspirin in the Cardiovascular System
Ruben Casado-Arroyo, Angel Lanas, and Pedro Brugada
Chapter 10. Adverse Effects of Low-Dose Aspirin in the Gastrointestinal Tract
Katsunori Iijima
Chapter 11. Aspirin in the Treatment and Prevention of Cardiovascular Disease: Need for Individual Clinical Judgments
Angel Lanas and Charles H. Hennekens
Section 4. NSAIDS and Aspirin in Cancer Prevention
Chapter 12. Molecular and Experimental Basis for COX-Inhibition in Cancer
Annalisa Bruno, Melania Dovizio, and Paola Patrignani
Chapter 13. Clinical Effects of NSAIDs and Coxibs in Colon Cancer Prevention
Elena Piazuelo and Angel Lanas
Chapter 14. Aspirin and the Prevention of Colorectal Cancer
Paul J. Lochhead and Andrew T. Chan
Chapter 15. A Rational Approach for the Use of NSAIDs and/or Aspirin in Cancer Prevention in the Near Future: “Balancing Risk and Benefits”
Elizabeth Half, Ahmad Fokra, and Nadir Arber