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An Introduction to Medicinal Chemistry (6th Ed.)

Langue : Anglais

Auteur :

Couverture de l’ouvrage An Introduction to Medicinal Chemistry
For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market?

An Introduction to Medicinal Chemistry, sixth edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part one of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development.
. 1: Drugs and drug targets - an overview

Part A - Drug targets - structure and function
. 2: Protein structure and function
. 3: Enzymes: structure and function
. 4: Receptors: structure and function
. 5: Receptors and signal transduction
. 6: Nucleic acids: structure and function

Part B - Pharmacodynamics and pharmacokinetics
. 7: Enzymes as drug targets
. 8: Receptors as drug targets
. 9: Nucleic acids as drug targets
. 10: Miscellaneous drug targets
. 11: Pharmacokinetics and related topics
. Case study 1: Statins

Part C - Drug discovery, design, and development
. 12: Drug discovery: finding a lead
. 13: Drug design: optimizing target interactions
. 14: Drug design: optimizing access to the target
. 15: Getting the drug to market
. Case study 2: The design of ACE inhibitors
. Case study 3: Artemisinin and related antimalarial drugs
. Case study 4: The design of oxamniquine

Part D - Tools of the trade
. 16: Combinatorial synthesis
. 17: Computers in medicinal chemistry
. 18: Quantitative structure-activity relationships (QSAR)
. Case study 5: De novo design of a thymidylate synthase inhibitor

Part E - Selected topics in medicinal chemistry
. 19: Antibacterial agents
. 20: Antiviral agents
. 21: Anticancer agents
. 22: Cholinergics, anticholinergics, and anticholinesterases
. 23: Drugs acting on the adrenergic nervous system
. 24: Opioid analgesics
. 25: Antiulcer agents
. 26: Cardiovascular drugs
. Case study 6: Steroidal anti-inflammatory agents
. Case Study 7: Design of a novel antidepressant
. Case Study 8: The design and development of aliskiren
. Case Study 9: Factor Xa inhibitors
. Case Study 10: Reversible inhibitors of HCV NS3-4A protease

. Appendices
Graham Patrick, Lecturer in Organic Chemistry and Medicinal Chemistry, University of the West of Scotland

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Ouvrage de 877 p.

20.2x26.5 cm

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59,20 €

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