α-Tertiary Amines en Route to Natural Products Visual Guides to Natural Product Synthesis Series

Langue : Anglais

Auteurs : Hameed Abdul, Al-Rashida Mariya, Shah Muhammad Raza

Couverture de l’ouvrage α-Tertiary Amines en Route to Natural Products

Résumé
Sommaire
Biographie
Commentaire

a-Tertiary Amines en Route to Natural Products presents the multistep synthesis of natural products using schematic diagrams. This approach provides a quick-and-easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. The book covers the class of natural products bearing the a,a-disubstituted a-amino acid motif. Featured natural product molecules include Altemicidin, Amathaspiramide (A-F), Kaitocephalin, Lactacystin, Salinosporamide, Manzacidins (A,C), Neooxazolomycin, Sphingofungins (E,F), (1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid (ACPD), Total synthesis of cephalotaxine and related molecules, a-amino acids based natural products, a amino acid based natural products and Tetrodotoxin.

This book is ideal for chemists working in the area of organic synthesis, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis.

1. Introduction: a,a-Disubsituted a-Amino Acids 2. Altemicidin 3. Amathaspiramide(A-F) 4. Kaitocephalin 5. Lactacystin 6. Salinosporamide 7. Manzacidins (A, C) 8. Sphingofungins (E, F) Synthesis 9. ACPD ((1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid) 10. Miscellaneous alkaloids: (+)-LY35470, Piperidine based alkaloids and Tetrodotoxin 11. Introduction: a,a-Disubsituted a-Amino Acids 12. Altemicidin 13. Amathaspiramide(A-F) 14. Kaitocephalin 15. Lactacystin 16. Salinosporamide 17. Manzacidins (A, C) 18. Sphingofungins (E, F) Synthesis 19. ACPD ((1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid) 20. Miscellaneous alkaloids: (+)-LY35470, Piperidine based alkaloids and Tetrodotoxin

Dr. Abdul Hameed Dr. Abdul Hameed completed his PhD in Organic Chemistry from The University of Nottingham, UK. He worked in the area of natural products synthesis. He was a post-doc fellow in Max-Planck Institut für Polymerforschung, Germany in synthetic division headed by Prof. Dr. Klaus Müllen. There he worked on the functionalization of adenylyl cyclsase inhibitors via chemical methods to conjugate them with monoclonal antibody to study their biological potential in Regulatory T cells (Treg). His current research interests are including the development of novel methodologies, their utilization in natural products synthesis, the synthesis heterocyclic compound compounds to evaluate their biological potential.
Dr. Mariya al-Rashida is a synthetic chemist and has expertise in the area of organic synthesis. She completed Ph.D. in chemistry from the Institute of Chemistry, University of the Punjab, Lahore, Pakistan in 2011. Her area of expertise is synthetic and computational medicinal chemistry. She is currently working towards the synthesis of metalloenzyme inhibitors (carbonic anhydrase, and ecto-nucleotidases). She is an Associate Professor and Chairperson of the Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan. She has published more than 60 research articles with a cumulative Impact Factor > 150 in various peer review international journals. She has been the recipient of many awards including the prestigious CSP Gold Medal Award for Chemist Under 40.
Muhammad Raza Shah is a full professor at the International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research. He is a recipient of several awards, including the Tamgha-i-Imtiaz Award from the President of Pakistan, the Salam Prize, the Professor Atta ur Rahman Gold Medal, and the Dr M Raziuddin Siddiqi Prize, by the Pa

Outlines synthetic strategies for natural products bearing a-tertiary amines and a,a-disubstituted a-amino acid motif
Describes multistep synthetic routes that highlight key steps
Covers asymmetric and diastereoselective synthetic approaches towards targeted natural products
Illustrates multistep synthetic routes related to -amino acids based natural products and -amino acids based natural products