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Microfluidics for Pharmaceutical Applications From Nano/Micro Systems Fabrication to Controlled Drug Delivery Micro and Nano Technologies Series

Langue : Anglais

Coordonnateurs : Santos Hélder A., Liu Dongfei, Zhang Hongbo

Couverture de l’ouvrage Microfluidics for Pharmaceutical Applications

Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening.

These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications.

Section I: Principle of microfluidics 1. Lab-on-a-Chip technology and microfluidics2. Fluid properties and hydrodynamics of microfluidic systems3. Diffusion and mixing in microfluidic device4. Microfluidic production of multicomponent multiple emulsions

Section II: Microfluidics for drug delivery applications 5. Microfabrication and Microfluidic Devices for Drug Delivery6. Lab-on-a-chip preparation routes for organic nanomaterials for drug delivery7. Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems8. Microfluidic production of inorganic nanomaterials for biomedical applications9. Lab-on-a-chip synthesis of microparticles for drug encapsulation and controlled release10. Microfluidic technologies for local drug delivery11. Droplet-based microfluidics for cell encapsulation and delivery12. Antibody discovery using microfluidic systems13. Single-cell screening using microfluidic systems

Section III: Microfluidics for analysis and drug delivery14. Lab-on-a-chip techniques for high throughput proteomics and drug discovery15. Microfluidics for chemical analysis and sample manipulation for pharmaceutical applications

Section IV: Future prospective and commercialization of microfluidic techniques16. Future of microfluidics in research and in the market

Prof. Santos (D.Sc. Tech., Chem. Eng.) is a Full Professor in Department of Biomedical Engineering at the University of Groningen. He is also Research Director at the University of Helsinki, Faculty of Pharmacy. Prof. Santos is also the co-founder of the startups Capsamedix Oy and Medixmicro Oy, and Coordinator of MSCA-ITN P4 FIT network in tendon repair (~4.1 m€). He holds Visiting Professorships at the Shanghai Jiao Tong University School of Medicine and University of Tartu. Prof. Santos research interests include the development of nanoparticles/nanomedicines and biomaterials for biomedical applications, particularly cancer and heart diseases. His lab makes the unique bridge between medical engineering, pharmaceutical nanotechnology and tissue engineering by combining unique techniques to develop novel therapeutic formulations for translation into the clinic. He is also in Editorial board member of several international journals, and Associate Editor of Nano Select, Smart Materials in Medicine, and Drug Delivery and Translational Research, among others. Prof. Santos has received prestigious awards/grants, for example, the "Talent Prize in Science" in 2010 attributed by the Portuguese Government, ERC Starting Grant in 2013 and ERC Proof-of-Concept Grant in 2018, Young Researcher Award in 2013 attributed by Faculty of Pharmacy, the Academy of Finland Award for Social Impact in 2016, and the CRS Young Investigator Award 2021.
Dongfei Liu is a Postdoctoral Fellow and PI at the Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland. He has developed a versatile and robust microfluidics platform to prepare extremely stable drug nanocrystals.
Hongbo Zhang is an Assistant Professor at Åbo Akademi, Finland. His research focuses on nanostructured materials prepared by microfluidics for drug delivery applications.
  • Presents detailed coverage on the fabrication of novel drug delivery systems with desired characteristics, such as uniform size, Janus particles, and particular or combined responsiveness
  • Includes a variety of case studies that explain principles
  • Focuses on commercialization, cost, safety, society and educational issues of microfluidic applications, showing how microfluidics is used in the real world

Date de parution :

Ouvrage de 495 p.

19x23.3 cm

Disponible chez l'éditeur (délai d'approvisionnement : 14 jours).

174,92 €

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Mots-clés :

3-D printing; ADME; Antibodies; Antimicrobial; B cells; Biomaterials; Biomedical; Biosensors; Cell deliveryPlease check whether the suggested running head “Droplet-based microfluidics for cell encapsulation” is appropriate for this chapter.-->; Cell encapsulation; Chaotic mixer; Continuous manufacturing; Contrast agents; Controlled drug delivery; Controlled release; Dimensionless numbers; Droplet; Droplet microfluidics; Droplet-based microfluidics; Droplets; Drug delivery; Drug screening; Drug testing; Emulsification; Emulsion; Encapsulation; Fluid properties; Gradient generator; High throughput; High-throughput; High-throughput preparation; InDrops; Industry 4.0; Joined PCR product; Lab-on-a-chip; Lab-on-a-chip techniques; Lipid nanoparticle; Localized drug delivery; Micelles; Microcapsules; Microchannel; Microdroplet; Microfluidic device; Microfluidic mixer; Microfluidic types; Microfluidics; Microgel; Mixing; Multicomponent; Nanocarrier; Nanomedicine; Nanomedicines; Nanopharmaceutical; Nanoprecipitation; Nanowells; Newtonian fluids; Organ-on-a-chip; PDMS; Personalized medicine; Pharmaceutical applications; Polymeric microparticles; Pressure-driven flows; Proteomics; Scale-up; Single-cell RNA-Seq; Single-cell screening and sequencing; Stimuli-responsive polymers; Theragnostics; Three-dimensional cell culture; Tissue engineeringPlease check whether the suggested running head “Nanomaterials in biomedical applications” is appropriate for this chapter.-->; Wearables