Microbial Reagents in Organic Synthesis, 1992 Nato Science Series C: Series, Vol. 381

Proceedings of the NATO Advanced Research Workshop, Sestri Levante, Italy, March 23-27, 1992

C-C Bond Formation.- Cyclase mediated synthesis of terpenoids.- (R)- and (S)-Cyanohydrins — Their enzymatic synthesis and their reactions.- Chemical-enzymatic synthesis of carbohydrates.- A building block strategy for asymmetric synthesis: the DHAP-aldolases.- Transferase catalyzed synthesis: applications in series of aminoacids and monosaccharides.- Acyloin formation mediated by benzoylformate decarboxylases.- Synthetic Applications.- Organic synthesis via biocatalytic methods — A chemoenzymatic approach to the synthesis of FK506.- Use of enzymes as catalysts in key reactions leading to the synthesis of optically active natural products and analogues.- New enzymatic methods for the selective functionalization of carbohydrate derivatives.- Efficient synthesis of optically active carbohydrates and other oxygenated compounds through bio-oxidation of chlorinated aromatics.- Chemoenzymatic synthesis of natural products and bioactive compounds.- Biotransformations applied to the synthesis of vitamins and pharmaceuticals.- Hydrolytic and Proteolytic Enzymes.- A direct route from hydantoins to D-amino acids employing a resting cell biocatalyst with D-hydantoinase and D-carbamoylase activity.- The use of immobilized penicillin G acylase in organic synthesis.- Are proteases suitable tools for the formation of peptide bonds?.- Enzymatic aminolysis, hydrazinolysis and oximolysis reactions.- Microbial and enzymatic transformation of nitriles.- Resolution of racemates with lipases and effect of reaction conditions on enantioselectivity.- Selectivity enhancement of Candida cylindracea lipase: covalent enzyme modification and control of micro-pH.- Lipase catalyzed organic synthesis.- Kinetics and validation of mathematical models of enantioselective transesterification in organicsolvents.- Enzymatic enantioselective ester hydrolysis by carboxylesterase NP.- A kinetic interpretation of acids and alcohols influence on the enantioselectivity in enzyme catalysed resolutions.- Asymmetrized tris(hydroxymethyl)methane and related synthons as new highly versatile chiral building blocks. Chemoenzymatic preparation and synthetic applications.- Oxidations.- A comparative study of chemical versus biological functionalizations of synthetic intermediates.- Enantioselective sulfoxidations catalyzed by chloroperoxidase and horseradish peroxidase.- Use of biooxygenation in fine organic synthesis.- The enzymatic Baeyer-Villiger oxidation.- Beauveria Sulfurescens mediated oxidation of dihydroartemisin derivates.- Reductions.- Comparison of chemical and biochemical reduction methods for the synthesis of (R)-2-hydroxy-4-phenylbutyric acid.- Stereochemical control in microbial reduction.- Approaches to 2-methyl-l-alkanols of high enantiomeric purities via enzyme mediated reactions.- Microbial alcohol/aldehyde oxidoreductases in enantioselective conversions.- Stereocontrolled reduction of ?-ketoesters with Geotriehum candidum.- Usefull enzymes from plant cell and organ cultures.- List of Contributors.- List of Participants.