Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates
Auteur : Postigo Al
Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work.
1. Introduction and Highlights2. 18F radiolabeling of bioactive compounds 3. Electrophilic and oxidative fluorination of aromatic compounds4. Enantioselective fluorination5. Visible-Light-Mediated C-F bond Activation6. Photocatalytic fluorination reactions7. Fluorination of allylic positions towards the synthesis of fluorinated bioactive compounds8. Difluoromethylation of Bioactive Compounds9. Fluorination of Bioactive Compounds by Electron Transfer Reactions10. Fluorine-Containing Pharmaceuticals and the Phenomenon of Self-Disproportionation of Enantiomers (SDE)
Medicinal Chemists, Synthetic Chemists, Pharmaceutical Scientists, Drug Discovery Researchers, Academia
- Highlights the latest developments in the field in a concise volume
- Provides details of key fluorinating reagents across diverse families of organic compounds
- Explores the current applications and future potential of fluorine in drug development
Date de parution : 09-2018
Ouvrage de 390 p.
15x22.8 cm
Thème de Late-Stage Fluorination of Bioactive Molecules and... :
Mots-clés :
18F-labeled radiopharmaceuticals; Achiral chromatography; Activation; Allylic fluorides; Anionic phase-transfer catalysis; Aromatic compounds; Arylcyclopropane; Bioactive compounds; C-F bond; Catalytic asymmetric synthesis; Chirality; dehydroxyfluorination; deoxyfluorination; Difluoromethyl synthons; Difluoromethylating reagents; Difluoromethylation reactions; Difluoromethyl-substituted bioactive compounds; Distillation; Drugs; Fluorine atom substitution; Electron transfer reactions; Enamine catalysis; FFluorine and compounds; fluorination; fluorodesilylation; Fluorination; Fluorine-18Low molar activity; Heterocycle; Higher-order species; Homo- and heterochiral interactions; Hydrogen atom transfer; Intermolecular interactions; Late-stage fluorination strategies; Lewis acid catalyst; NF-Reagents; Organocatalyst; Perfluoroalkylation; Pharmaceuticals; Photocatalysis; Photocatalyzed difluoromethylation; Positron emission tomography (PET)Prostate specific membrane antigen; Positron emission tomography; Radical ions; Radical; Radicals; Radiofluorination; Reagent; Selectfluor; Selectfluor; Self-disproportionation of enantiomers (SDE)Sublimation; Solvent-free conditions; TEMPO; Transition metal difluoromethylation reactions; trichloroacetimidates; Trifluoromethyl; Trifluoromethylation; Visible light