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Discovery and Development of Antidiabetic Agents from Natural Products Natural Product Drug Discovery Natural Product Drug Discovery Series

Langue : Anglais

Auteur :

Couverture de l’ouvrage Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic.

Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications.

Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics.

  • Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery
  • Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues
  • Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Chapter 1. Andrographolide: A Molecule of Antidiabetic Promise

Chapter 2. Computer-Aided Discovery of Glycogen Phosphorylase Inhibitors Exploiting Natural Products

Chapter 3. Identification and Extraction of Antidiabetic Antioxidants from Natural Sources

Chapter 4. Glucose Transporter 4 Translocation Activators From Nature

Chapter 5. Carbohydrate-Based Antidiabetic Agents From Nature

Chapter 6. Recent Developments on the Antidiabetic Sesquiterpene Lactones and Their Semisynthetic Analogues

Chapter 7. Prediction of Prediabetes and Its Prevention by Functional Food Compounds

Chapter 8. Immunomodulators in Prophylaxis and Therapy of Type-1 Diabetes

Chapter 9. α-Glucosidase Enzyme Inhibitors From Natural Products

Chapter 10. Treasures of Indigenous Indian Herbal Antidiabetics: An Overview

Primarily medicinal chemists and researchers into antidiabetic drug design and drug leads from natural products, with a secondary audience of pharmacologists, biochemist and medical professionals involved in pre-clinical testing, clinical trials and application of antidiabetic drugs. Also of interest to post-grad and academic researchers in these fields

Goutam Brahmachari is a professor of organic chemistry at Visva-Bharati, India, and teaches courses in organic chemistry, natural products chemistry, synthetic organic chemistry, and physical methods in organic chemistry. In addition to over 20 years of teaching and research experience, he is a Fellow of the Royal Society of Chemistry, a Who’s Who in the World Listee, and a recipient of Academic Brilliance Award (2015) for Excellence in Research and the Dr. Kalam Best Teaching Faculty Award (2017). Prof. Brahmachari serves as journal referee, editor-in-chief, associate editor, guest editor, and Editorial Advisory Board Member for several international journals, book publishers, and research funding agencies. He has over 190 publications in the fields of organic and medicinal chemistry, including 22 books and over 40 book chapters, published by internationally reputed publishers.

Date de parution :

Ouvrage de 332 p.

15.2x22.9 cm

Disponible chez l'éditeur (délai d'approvisionnement : 14 jours).

158,56 €

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