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Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules, 1st ed. 2019 The Shape of Organic Synthesis to Come

Langue : Anglais

Coordonnateur : Kobayashi Yuichi

Couverture de l’ouvrage Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules

This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.

1. Microbial Fraction Library: A Screening Source for Drug Discovery

Toshihiko Nogawa, Julius Adam V. Lopez, and Hiroyuki Osada


2. Efficient Total Synthesis of Ōmura Natural Products

Toshiaki Sunazuka, Tomoyasu Hirose and Satoshi Ōmura


3. Enantioselective Total Synthesis of the Antitumor Polycyclic Natural Products, FR182877 and Taxol
Masahisa Nakada


4. Synthetic Approaches on the Pluramycin-class Antibiotics
Yoshio Ando, Kei Kitamura, Takashi Matsumoto and Keisuke Suzuki


5. Recent Progress Toward the Total Synthesis of Duocarmaycins A and SA, Yatakemaycin, and PDE-I and –II
Juri Sakata and Hidetoshi Tokuyama


6. Structure-Activity Relationship Studies of Maitotoxin Based on Chemical Synthesis
Tohru Oishi


7. Substitution of Allylic Picolinates with Various Copper Reagents and Synthetic Applications
Yuichi Kobayashi and Miwa Shimoda


8. Total Synthesis of Ingenol
Tyler F. Higgins and Jeffrey D. Winkler


9. Strategies for Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids
Yuichi Kobayashi and Masao Morita


10. Biosynthesis, biological functions, and receptors of leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid
Toshiaki Okuno and Takehiko Yokomizo


11. Synthesis of classical/non-classical hybrid cannabinoids and related compounds
Thanh C. Ho and Marcus A. Tius


12. Exploring bioactive marine natural products and identification of their molecular targets
Masayoshi Arai


13. Target protein chemical modification
Hiroyuki Nakamura


14. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes
Suguru Yoshida and Takamitsu Hosoya

Yuichi KOBAYASHI received Ph.D. from the Tokyo Institute of Technology in 1981. His supervisors were Professors Jiro Tsuji and Fumie Sato at the Tokyo Institute of Technology and Gibert Stork at Columbia University. He is a full Professor at Tokyo Institute of Technology. His research interests include organic synthesis using transition metal catalysts and developments of chiral C–C bond formation. Targets include fatty acid metabolites known as resolvins and leukotrienes, isoprostanes, epi-jasmonates, tetrahydrocannabinoids, cinchona alkaloids, phoslactomycins, etc. The picolinoxy leaving group in allylic substitution has created tertially and quaternary carbons. These achievements have been published in internationally renowned journals such as Angew. Chem. Int. Ed., Org. Lett., Nature, Chem. Eur. J. He has 35 years of teaching experience at the Tokyo Institute of Technology. 

Presents a quick survey of topics in organic synthesis for top researchers, young chemists, graduate students, and those looking for new research based on organic chemistry 

Suggests future research based on organic synthesis   

Enables understanding of the purpose and major results of the contents with schemes and illustrations 

Date de parution :

Ouvrage de 355 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

116,04 €

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