Complete Accounts of Integrated Drug Discovery and Development Recent Examples from the Pharmaceutical Industry (Volume 1) ACS Symposium Series

The chapters in this book are written to accentuate the interdependency and synergy between drug discovery and process development disciplines to advance a new chemical entity into clinical trials and eventually to the market. Due to the success of our previous books (Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development, Volumes 1 and 2), the editors sought to further arm experienced modern synthetic organic chemists, and budding researchers perhaps still in universities with real world examples from the pharmaceutical industry. In addition, the chapters contain citations of a large number of valuable selected references to the primary literature. The book highlights the tireless efforts of Discovery and Process Chemists, and their roles in the advancement of drug discovery and development. The editors were motivated to create this book by our appreciation of the value of chemical research by both Discovery and Process Chemists in producing new pharmaceutical entities. Their combined efforts make it possible to introduce novel and effective drugs into the market to treat hundreds of millions of patients and alleviate their suffering, improve their quality of life and possibly save their lives from diseases and disorders. The chapters presented in this book are written by a selected group of outstanding, highly accomplished Medicinal and Process Chemists with noted experiences and diverse backgrounds representing some of the top pharmaceutical companies. The chapters highlight examples of emerging concepts, new developments and challenges arising in the discovery of new drug candidates and the development of new practical synthetic chemistry processes to produce these drug candidates on large scale. The story leading up to the discovery of each drug or drug candidate is presented by the Discovery Chemist(s), and then the Process Chemist(s) describe the development of the same drug to give the reader a complete story of drug discovery and development. The reader will experience a rare and unique opportunity to obtain the complete perspectives of Discovery and Process Chemistry in a single book. While most of these topics have appeared in the primary literature where space is critical and brevity valued, the book permits the editors and contributors to tell the complete tales as stories, from start to finish or to the current state of the drug development.

Ahmed F. Abdel-Magid was born in Giza, Egypt in 1947. He received his Bachelor's degree (1969) and Master's degree (1973) from Cairo University (Cairo, Egypt) and his Ph.D. (1980) from Temple University (Philadelphia, PA USA). After postdoctoral appointments at the University of South Carolina (Columbia, SC) and SmithKline Beckman Pharmaceuticals (Philadelphia, PA), he worked at Drexel University (Philadelphia, PA) as Teaching/Research Associate (1985-1986), then as an Adjunct Professor (1986-2006). He joined the Process Chemistry Department at Wyeth Laboratories as Senior Chemist (1986-1987), after which he moved to the Process Chemistry Group at Johnson & Johnson PRD (1987-2008) as a Senior Scientist and rose through the ranks to Senior Research Fellow. He joined Therachem Research Medilab in 2009, where he holds the titles of Executive VP and Chief Scientific Officer. Organic Process Research was his focus for 32 years: he contributed to the development of more than 50 processes including 5 for the commercial manufacture of marketed drugs. He is the inventor of 28 issued patents, editor of 6 books, author of 40 publications and 130 medicinal chemistry patent highlights published in ACS Medicinal Chemistry Letters. He served as the Executive Officer and Chair of the 39th National Organic Chemistry Symposium (NOS) held at the University of Utah in June 2005. He also served as the National Program Chair and member of the Executive Committee of the Division of Organic Chemistry of the ACS (2008-2014), and he is a Patent Panelist for ACS Medicinal Chemistry Letters (2012-Present). His awards include: the Philip B. Hofmann Award for Outstanding Research from Johnson & Johnson (1994), the Philadelphia Organic Chemists' Club Award for Outstanding Contributions to Organic Chemistry (2007), the ACS-Philadelphia Section Award for Conspicuous Scientific Achievement Through Research (2013), and he is a Fellow of the American Chemical Society (Inaugural class, 2009). Jaan A.