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Voltage Gated Sodium Channels, Softcover reprint of the original 1st ed. 2014 Handbook of Experimental Pharmacology Series, Vol. 221

Langue : Anglais

Coordonnateur : Ruben Peter C.

Couverture de l’ouvrage Voltage Gated Sodium Channels
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels, and the techniques with which their biophysical and structural properties are studied.
Overview:biophysical properties and structure of sodium channels.- The voltage sensor module in sodium channels.- Slow inactivation of Na+ channels.- Regulation/modulation of sensory neuron sodium channels.- Ubiquitylation of voltage-gated sodium channels.- Probing gating mechanisms of sodium channel using pore blockers.- Animal toxins influence voltage-gated sodium channel function.- Voltage-sensor trapping toxins: Isoform-specific ligands for sodium channels.- Pharmacological insights and quirks of bacterial sodium channels.- The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels.- The role of late INa in development of cardiac arrhythmias.- Proton modulation of cardiac INa: A potential arrhythmogenic trigger.- Altered sodium channel gating as molecular basis for pain: Contribution of activation, inactivation and resurgent currents. 

Gives unprecedented insight into the structural basis of sodium channel function

Explores sodium channels from the perspectives of their biophysical behavior

Written by leading experts in the field

Date de parution :

Ouvrage de 295 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 325,36 €

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Date de parution :

Ouvrage de 295 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 348,14 €

Ajouter au panier
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