Translational Biology in Medicine Woodhead Publishing Series in Biomedicine Series
Auteur : Montano M.
- Dedication
- List of figures
- Abbreviations
- About the author
- 1: Introduction and overview of chapter contents
- Abstract
- 2: Model systems
- Abstract
- 2.1 Introduction
- 2.2 Immortalized cell lines
- 2.3 Primary cells obtained from the host
- 2.4 Animal models
- 2.5 Stem cells: adult and induced pluripotent
- 3: Blood biomarkers: overview of existing serum test strategies for disease severity, risk for progression, therapeutic benchmark targets
- Abstract
- 3.1 Introduction
- 3.2 Early definition of biomarkers
- 3.3 Initial biomarker discovery
- 3.4 Translation into animal models
- 3.5 Translation into small human populations
- 3.6 Application to larger, more generalizable populations
- 3.7 Biomarker measurement considerations
- 4: Genetic and genomic profiling
- Abstract
- 4.1 Introduction
- 4.2 Theories of heritability of disease risk and severity
- 4.3 Gene expression signatures
- 4.4 Examples of gene expression signatures
- 5: Translational models, methods and concepts in studies of aging and longevity
- Abstract
- 5.1 Introduction
- 5.2 Theories of aging
- 5.3 The here and now: the world is aging
- 5.4 Telomere length/activity in aging
- 5.5 Stem cell aging
- 5.6 Aging and muscle tissue regeneration
- 5.7 Immune aging and immunosenescence
- 5.8 The insulin/IGF1 signaling axis in aging
- 5.9 Branched-chain amino acids (BCAA) and aging
- 5.10 Measurement of lifespan modulators
- 5.11 Factors influencing aging
- 6: Translational models, methods and concepts in studies of muscle tissue repair
- Abstract
- 6.1 Introduction
- 6.2 Muscle maintenance and regeneration
- 6.3 The role of satellite cell activity in aging and decline in muscle function
- 6.4 Muscle growth regulatory pathways
- 6.5 Sarcopenia and muscle maintenance
- 6.6 Functional limitations and therapeutic drug design
- 6.7 The TGFb1 axis
- 6.8 Inflammatory stress and muscle
- 6.9 Cachexia and muscle homeostasis
- 6.10 Anabolic effects of testosterone treatment
- 6.11 Use of high-throughput technologies with muscle to promote musculoskeletal growth
- 7: Translational models, methods and concepts in studies of acute and chronic infection
- Abstract
- 7.1 Introduction
- 7.2 From HIV origins to the modern era
- 7.3 HIV infection and aging
- 7.4 HIV-1 infection and transmission
- 7.5 Infection and innate host response
- 7.6 HIV and adaptive host response
- 7.7 HIV-1 comorbid conditions
- 7.8 HIV and drugs
- 7.9 Infection-associated inflammation and aging promote fibrosis
- 7.10 Viral eradication studies
- 8: Bioethical considerations and IRB challenges in translational biology study design and bioethical considerations in biomedical research
- Abstract
- 8.1 Institutional review boards
- 8.2 Institutional animal care and use committee (IACUC)
- 8.3 Big Data and the online privacy of health information
- 9: Concluding remarks and the future of personalized medicine
- Abstract
- 9.1 Introduction
- 9.2 Personalized medicine and aging
- 9.3 Personalized medicine and muscle maintenance
- 9.4 Personalized medicine and infectious diseases: HIV
- References
- Index
personalized supplements that optimize gains in and reduce losses of muscle mass.
- Describes cellular and animal model systems used in translational research
- Discusses the use of blood, genetic and genomic biomarkers for disease
- Presents translational studies in aging, tissue repair and infectious disease biomedicine
Date de parution : 10-2018
Ouvrage de 228 p.
15.5x23.2 cm
Publication abandonnée
Date de parution : 08-2014
Ouvrage de 228 p.
15.5x23.2 cm
Épuisé
Thèmes de Translational Biology in Medicine :
Mots-clés :
Biomedicine; Translational medicine; Cell systems; Drug discovery; Personalized medicine