Transient Receptor Potential Channels, Softcover reprint of the original 1st ed. 2011 Advances in Experimental Medicine and Biology Series, Vol. 704

Transient Receptor Potential Channelsoffers a unique blend of thoughtfully selected topics ranging from the structural biology of this fascinating group of ion channels to their emerging roles in human diseases. This single book covers TRP channels of yeasts, flies, fishes frogs and humans. And from the biophysics of primary thermo-sensory events in cells to the thermosensation at whole organism level, from physiology of pain to the development of pain-killers, from psychiatric illnesses to cancers, from skin cells to sperms, from taste buds to testes, from established facts to heated debates, this book contains something for every TRP enthusiasts, beginner and expert alike. It includes crucial background information, critical analysis of cutting edge research, and ideas and thoughts for numerous testable hypotheses. It also shows directions for future research in this highly dynamic field. It is a book readers will be just as eager to give to others as keep for themselves.

Contents. Preface. 1. Structural biology of TRP channels. 2. Functional and structural studies of TRP channels heterologously expressed in budding yeast. 3. Natural product ligands of TRP channels. 4. Synthetic modulators of TRP channel activity. 5. Study of TRP channels by automated patch clamp systems. 6. TRPC2: of mice but not men. 7. TRPM1: New trends for an old TRP. 8. The non-selective monovalent cationic channels TRPM4 and TRPM5. 9. TRPM7, the Mg2+ inhibited channel and kinase. 10. TRPM8 in health and disease: cold sensing and beyond. 11. TRPML1. 12. TRPML2 and the evolution of mucolipins. 13. The TRPML3 channel: from gene to function. 14. TRPV5 and TRPV6 in transcellular Ca2+ transport: regulation, gene duplication, and polymorphisms in African populations. 15. The TRPV5 promoter as a tool for generation of transgenic mouse models. 16. TRPP channels and polycystins. 17. TRP channels in yeast. 18. C. elegans TRP channel. 19. Investigations of TRP channel function in vivo using frog and zebrafish model systems. 20. TRP channels in parasites. 21. Receptor signaling integration by TRP channelsomes. 22. Gating mechanisms of canonical transient receptor potential channel proteins:role of phosphoinositols and diacylglycerol. 23. The TRPC ion channels: association with Orai1 and STIM1 proteins and participation in capacitative and non-capacitative calcium entry. 24. Contribution of TRPC1 and Orai1 to Ca2+ entry activated by store depletion. 25. Primary thermosensory events in cells. 26. ThermoTRP channels: biophysics of polymodal receptors. 27. Complex regulation of TRPV1 and related thermoTRPs: implications for therapeutic intervention. 28. Voltage sensing in thermo TRP channels. 29. TRP channels as mediators of oxidative stress. 30. Regulation of TRP signaling by ion channel translocation between cell compartments. 31. Emerging roles of canonical TRP channels in neuronal function. 32. TRP channels and neural persistent activity. 33. Role of TRP channels in pain sensation. 34. TRPV1: a therapy target that attracts the pharmaceutical interests. 35. Expression and function of TRP channels in liver cells. 36. Expression and physiologial roles of TRP channels in smooth muscle cells. 37. TRPM channels in the vasculature. 38. Molecular expression and functional role of canonical transient receptor potential channels in airway smooth muscle cells. 39. TRP channles in skeletal muscle: gene expression, function and implication for disease. 40. TRP Channels in vascular endothelial cells. 41. TRP channels in the cardiopulmonary vasculature. 42. TRP channels of islets. 43. Multiple roles for TRPs in the taste system: not your typical TRPs. 44. Roles of transient receptor potential proteins (TRPs) in epidermal keratinocytes. 45. TRP channels in urinary bladder mechanosensation. 46. The role of TRP ion channels in testicular function. 47. TRP channels in female reproductive organs and placenta. 48. Oncogenic TRP channels. 49. TRPV channels in tumor growth and progressio. 50. The Role of Transient Receptor Potential Channels in Respiratory Symptoms and athophysiology. 51. TRP channels and psychiatric disorders. 52. Transient receptor potential genes and human inherited disease.

A gold-mine for ion channel researchers and electro-physiologists A must read for cell and molecular biologists A mile stone in molecular medicine A must read drug discovery A must read for cancer researchers, neuroscientists and diabetes researchers