Toxicology and Human Environments

Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments.

The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis.

1. Human Environments: Definition, Scope and the Role of Toxicology

Ernest Hodgson

2. Estimating Human Exposure: Improving Accuracy with Chemical Markers

Roger C. Cochran and Jeffrey H. Driver

3. Metabolism of Xenobiotics Human Environments

Edward Croom

4. Toxic Endpoints in the Study of Human Exposure to Environmental Chemicals

Andrew D. Wallace

5. Pesticide Regulations: Exposure-Dose Modeling from FIFRA to FQPA

James B. Knaak, Cecilla Tan and Curt C. Dary

6. Occupational Chemicals: Metabolism, Toxicity and Mode of Action

Sheila Flack and Leena A. Nylander-French

7. Chemicals of Military Deployments: Revisiting Gulf War Syndrome in Light of New Information

A.A. Brimfield

8. Pharmaceuticals in the Environment: Lessons Learned for Reducing Uncertainties in Environmental Risk Assessment

Bryan W. Brooks, Jason P. Berninger, Lauren A. Kristofco, Alejandro J. Ramirez, Jacob K. Stanley and Theodore W. Valenti

9. Quantitative Risk Assessment Methods for Cancer and Non-Cancer Effects

Ronald E. Baynes

10. Human Health Risk Assessment for Contaminated Properties

Atul M. Salhotra

11. The Future of Human Health Risk Assessment of Environmental Chemicals.

Ernest Hodgson

12. Ecological Risk Assessment

Damian Shea and Waverly Thorsen

13. Metabolic Interactions of Environmental Toxicants in Humans

Ernest Hodgson

14. Toxins and Venoms

Ernest Hodgson

15. Summary and Conclusions

Scientists and researchers interested in molecular biology, translational science, and toxicology

• Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health
• Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them