Tobacco smoke and involuntary smoking. Monographs on the evaluation of carcinogenic risks to humans. IARC N° 83

Involuntary smoking involves exposure to the same numerous carcinogens and toxic substances that are present in tobacco smoke produced by active smoking, which is the principal cause of lung cancer. As noted in the previous IARC Monograph on tobacco smoking, this implies that there will be some risk of lung cancer from exposure to secondhand tobacco smoke. More than 50 studies of involuntary smoking and lung cancer risk in never-smokers, especially spouses of smokers, have been published during the last 25 years. These studies have been carried out in many countries. Most showed an increased risk, especially for persons with higher exposures. To evaluate the information collectively, in particular from those studies with a limited number of cases, meta-analyses have been conducted in which the relative risk estimates from the individual studies are pooled together. These meta-analyses show that there is a statistically significant and consistent association between lung cancer risk in spouses of smokers and exposure to secondhand tobacco smoke from the spouse who smokes. The excess risk is of the order of 20% for women and 30% for men and remains after controlling for some potential sources of bias and confounding. The excess risk increases with increasing exposure. Furthermore, other published meta-analyses of lung cancer in never-smokers exposed to secondhand tobacco smoke at the workplace have found a statistically significant increase in risk of 12–19%. This evidence is sufficient to conclude that involuntary smoking is a cause of lung cancer in never-smokers. The magnitudes of the observed risks are reasonably consistent with predictions based on studies of active smoking in many populations.