Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (5^th Ed.)

As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics.

Section I: Principles of Laboratory Medicine

1. Introduction to Laboratory Medicine
2. Selection and Analytical Evaluation of Methods - With Statistical Techniques
3. Clinical Evaluation of Methods
4. Evidence Based Laboratory Medicine
5. Establishment and Use of Reference Values
6. Preanalytical Variables and Biological Variation
7. Specimen Collection and Processing
8. Quality Management

Section II: Analytical Techniques and Instrumentation

9. Principles of Basic Techniques and Laboratory Safety
10. Optical Techniques
11. Electrochemistry and Chemical Sensors
12. Electrophoresis
13. Chromatography and Extraction
14. Mass Spectrometry
15. Enzyme and Rate Analyses
16. Principles of Immunochemical Techniques
17. Nucleic Acid Techniques
18. Microfabrication and Microfluidics and Their Application to Clinical Diagnostics
19. Automation in the Clinical Laboratory
20. Point-of-Care Testing

Section III: Analytes

21. Amino Acids, Peptides, and Proteins
22. Serum Enzymes
23. Enzymes of the Red Blood Cell
24. Tumor Markers
25. Kidney Function Tests
26. Carbohydrates
27. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors
28. Electrolytes and Blood Gases
29. Hormones
30. Catecholamines and Serotonin
31. Vitamins and Trace Elements
32. Hemoglobin, Iron, and Bilirubin
33. The Porphyrias and Other Disorders of Porphyrin Metabolism
34. Therapeutic Drugs and Their Management
35. Clinical Toxicology
36. Toxic Metals

Section IV: Molecular Diagnostics and Genetics

37. Principles of Molecular Biology
38. Genomes and Nucleic Acid Alterations
39. Nucleic Acid Isolation
40. Inherited Diseases
41. Identity Assessment
42. Molecular Methods in Diagnosis and Monitoring of Infectious Diseases
43. Pharmacogenetics
44. Hematopoietic Malignancies
45. Plasma Nucleic Acids

Section V: Pathophysiology

46. Diabetes Mellitus
47. Cardiovascular Disease
48. Kidney Disease
49. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
50. Liver Disease
51. Gastrointestinal and Pancreatic Diseases
52. Disorders of Bone and Mineral Metabolism
53. Pituitary Function and Pathophysiology
54. The Adrenal Cortex
55. The Thyroid: Pathophysiology and Thyroid Function Testing
56. Reproductive Endocrinology and Related Disorders
57. Pregnancy and its Disorders
58. Newborn Screening and Inborn Errors of Metabolism
59. Hemostasis

Section VI: Appendix

60. Reference Information for the Clinical Laboratory