The Tumor Immunoenvironment, Softcover reprint of the original 1st ed. 2013
Coordonnateurs : Shurin Michael R, Umansky Viktor, Malyguine Anatoli
Preface Dmitry I. Gabrilovich
Introduction
Role of the immunological environment in cancer initiation, development and progression
Anatoli Malyguine, Viktor Umansky and Michael R. Shurin
Part I Tumor Microenvironment and Immunoenvironment
The metastatic microenvironment
Shelly Maman and Isaac P. Witz
Tumor infiltration by immune cells: pathologic evaluation and a clinical significance
Dmitri W. Gutkin
Immunologic interpretation of cancer biology: impact on clinical outcome
Maria Libera Ascierto, Ena Wang and Francesco M Marincola
Part II Developmental Characteristics of the Tumor ImmunoEnvironment
Development of antitumor cellular immunity
M.J.P. Welters and S.H. van der Burg
The versatile world of inflammatory chemokines in cancer
Tal Leibovich-Rivkin, Yaeli Lebel-Haziv, Shalom Lerrer, Polina Weitzenfeld and Adit Ben-Baruch
Inflammation, Tumor Progression, and Immune Suppression
Suzanne Ostrand-Rosenberg
Pleiotropic and differential functions of IL-1a and IL-1b shape the tumor microenvironment and affect the outcome of malignancies
Ron N. Apte and Elena Voronov
Impact of obesity and aging on the tumor immunoenvironment
Annie Mirsoian, Gail D. Sckisel, Anthony E. Zamora and William J. Murphy
Part III Tumor Escape from Immune Recognition
MHC class I antigens and the tumor microenvironment
Natalia Apsirauri, Teresa Cabrera, Angel Garcia-Lora, Francisco Ruiz-Cabello and Federico Garrido
Tumor-produced immune regulating factors
Mads Hald Andersen, Jürgen C. Becker and Per thor Straten
Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor-associated microenvironmentsYutaka Kawakami, Tomonori Yaguchi, Hidetoshi Sumimoto, Chie Kudo-Saito, Nobuo Tsukamoto, Tomoko Iwata-Kajihara, Shoko Nakamura, Hiroshi Nishio, Ryosuke Satomi, Asuka Kobayashi, Mayuri Tanaka, Jeong Hoon Park, Hajime Kamijuku, Takahiro Tsujikawa and Naoshi Kawamura
T cell malfunction in the tumor environment
Eitan Yefenof
Signaling of tumor-induced immunosuppression of dendritic cells
Yong Lu, Jing Yang and Qing Yi
Tumor microenvironment may shape the function and phenotype of NK cells through the induction of split anergy and generation of regulatory NK cells
Anahid Jewett and Han-Ching Tseng
Part IV Immune Regulators in the Tumor ImmunoEnvironment
The role of myeloid-derived suppressor cells in cancer
Jonathan Weiss
Macrophage differentiation and activation states in the tumor microenvironment
Jo A. Van Ginderachter
Dendritic cells and cancer: development, dysfunction and therapeutic targets
Stephanie K. Watkins and Arthur A. Hurwitz
The role of tumor-associated neutrophils in cancer
Zvi G. Fridlender
Mast cell modulation of the tumor microenvironment
Jean Marshall and Sharon Oldford
Regulatory T cells in patients with cancer
Theresa Whiteside
Tumor-evoked regulatory B cells as important mediators of cancer escape
Catalina Lee-Chang, Monica Bodogai and Arya Biragyn
Part V Tumor Escape and Cancer Immunotherapy
Cancer immunotherapy: Overview in brief
Philipp Beckhove
Programming of MDSC: New opportunities for targeted therapy
Peter Svider, Shu-Hsia Chen and Andy Sikora
Therapeutic targeting regulatory T cells in tumor
Wei Wang and Weiping Zou
ChemoImmunoModulation: Focus on myeloid regulatory cells
Viktor Umansky and Michael R. Shurin
Combining vaccines with therapies that render tumor cells more susceptible to immune mediated killing
Nishith Singh, James Hodge, Ravi Madan and James L. Gulley
Prophylactic Cancer Vaccines
Pamela L. Beatty and Olivera Finn
Part VI Analyzing Immune Responses in Cancer
Approaches to Immunologic Monitoring of Clinical Trials
Lisa H. Butterfield, Lazar Vujanovic and Angela Pardee
Evaluation of the tumor immunoenvironment in clinical trials
Anatoli Malyguine, Kimberly Dunham, Thomas Sayers and Michael R. Shurin
Analysis of Myeloid-derived Suppressor Cells in Patients with Cancer
Peiyuan Zhu, Yevgeniya V. Segal, Galina V. Shurin and Michael R. Shurin
When results of T cell immune monitoring match or do not match clinical outcomes of tumor vaccine trials - what more could and should we measure?
Paul V. Lehmann and Srividya Sundararaman
This is a unique and very first book summarizing current knowledge on immune cell functioning in cancer
Focus on both experimental animal results and human clinical trials
Prepared logically linked chapter in one comprehensive review of the field
Includes supplementary material: sn.pub/extras
Date de parution : 08-2016
Ouvrage de 745 p.
15.5x23.5 cm
Date de parution : 04-2013
Ouvrage de 745 p.
15.5x23.5 cm