The spectrum of neuro-AIDS disorders : Pathophysiology, diagnosis & treatment Pathophysiology, Diagnosis, and Treatment

This book covers new developments in the field of Neuro-AIDS in the HAART (highly-active antiretroviral therapy) era. It presents specific information on special populations affected by neuro-AIDS disorders, including women, minorities, children, and the elderly and explores medicolegal issues, including end-of-life issues specific to neuro-AIDS patients. It provides basic pathophysiology updates on topics such as viral evolution, chemokines, cerebrospinal fluid biomarkers, cell cycle proteins, and vaccines and neuro-AIDS and features new 2005 proposed diagnostic criteria for HIV-1-associated cognitive disorders.

Table of Contents Section I. Disorders Due to Primary HIV-1 Pathogenesis and Their Treatment 1. HIV-1-Associated Neurocognitive Disorders in the HAART Era, Karl Goodkin, Aaron Aronow, Gayle Baldwin, Rebeca Molina, and Wenli Zheng 2. Evolution of Neuropsychological Issues in HIV-1 Infection during the HAART Era, Thomas D. Marcotte and J. Cobb Scott 3. HIV Infection and Stroke: the Changing Face of a Rising Problem, Mauricio Concha and Alejandro Rabinstein 4. HIV-Associated Myelopathy, Myopathy, and Meningitis, Lydia Estanislao 5. Investigation and Presentation of Autonomic Neuropathies in HIV Infection, Roy Freeman and Rachel Nardin 6. Distal Sensory Polyneuropathy and Other Selected Neuropathies in HIV Infection, Lydia Estanislao, Anthony Geraci, and David Simpson 7. Mitochondrial Dysfunction and Lactic Acidosis in HIV Disease, Ashok Verma and Jorge Pardo 8. Neurologic Outcomes in HIV Infection: Clinical Events and Surrogate Markers, Constantin T. Yiannoutsos 9. Designing HIV gp120 Peptide Vaccines: Rhetoric or Reality for Neuro-AIDS? Pandjassarame Kangueane, Rajarathinam Kayathri, Meena Kishore Sakharkar, Darren R. Flower, Kristen Sadler, Francesco Chiappeli, David M. Segal, and Paul Shapshak Section II. Pathophysiological Issues 10. Neurovirological Aspects of HIV Infection in the HAART Era, Zahida Parveen, Edward Acheampong, Roger J. Pomerantz, and Muhammad Mukhtar 11. Neuroimmunology and the Pathogenesis of HIV-1 Encephalitis in the HAART Era: Implications for Neuroprotective Treatment, Seth W. Perry and Harris A. Gelbard 12. Chemokines and the Neuropathogenesis of HIV-1 Infection, Dawn Eggert, Eric Anderson, Jialin Zheng, and Howard E. Gendelman 13. Cerebrospinal Fluid Markers in the Management of Central Nervous System HIV Infection and the AIDS Dementia Complex, Magnus Gisslén, Lars Hagberg, Paola Cinque, Bruce Brew, and Richard W. Price 14. The Neuropathology of HIV Pre- and Post-HAART, Jutta K. Neuenburg 15. The Role of Viral Genetic Variability in HIV-1-Associated Neurocognitive Disorder, Paul Shapshak, Alireza Minagar, Pandjassarame Kangueane, Simon Frost, Sergei L. Kosakovsky Pond, Selene Zarate, Elyse Singer, Deborah Commins, Anne De Groot, Miguel Quinones-Mateu, and Ernest Terwilliger 16. Antioxidants and Brain Function in HIV/AIDS, Gail Shor-Posner, Adriana Campa, Maria-Jose Miguez-Burbano, Gloria Castillo, and Geraldine Moren-Black 17. Cell Cycle Proteins and the Pathogenesis of HIV-1 Encephalitis in the HAART Era, Kelly L. Jordan-Sciutto and Cagla Akay Section III. Neuroimaging in HIV Infection 18. The Uses of Structural Neuroimaging in the Brain in HIV-1-Infected Patients, Majda M. Thurnher and M. Judith Donovan Post 19. Functional Magnetic Resonance Imaging in HIV-Associated Dementia, Thomas Ernst, Dardo Tomasi, and Linda Chang 20. Magnetic Resonance Spectroscopy in HIV-Associated Brain Injury, Linda Chang, Kai Zhong, and Thomas Ernst Section IV. HIV Comorbidities 21. Hepatitis C Virus: Variability, Extrahepatic Replication, and Neuroinvasion, Marek Radkowski, Jonathan Nasseri, and Tomasz Laskus 22. Toxoplasmosis of the Central Nervous System, Katia V. Brown and Daniel J. Skiest 23. Basic and Clinical Aspects of Human Cytomegalovirus Infection, Robert R. McKendall and Alex Tselis 24. Cryptococcosis and Other Fungal Infections of the Central Nervous System, Roger J. Bedimo and Daniel J. Skiest 25. Neurosyphilis in AIDS, Joseph R. Berger and Aaron J. Berger 26. Progressive Multifocal Leukoencephalopathy in the Era of HAART, David B. Clifford 27. Epstein-Barr Virus Infection and Primary Central Nervous System Lymphoma, Alex Tselis and Robert R. McKendall 28. Mood Disorders, Delirium, and Other Neurobehavioral Symptoms and Disorders in the HAART Era, Stephen J. Ferrando and Todd Loftus 29. Substance Use Disorders and Neuro-AIDS in the HAART Era, Jeffrey A. Rumbaugh and Avindra Nath Section V. Special Populations and Neuro-AIDS 30. Ethnicity and Neuro-AIDS Conditions in the HAART Era, Loyda M. Meléndez, Raul Mayo-Santana, Carlos Luciano, and Valerie Wojna 31. Women and Neuro-AIDS Conditions in the Era of HAART, Gabriele Arendt, Y. Jaeger, and Th. Nolting 32. Pediatric Neuro-AIDS, Anita L. Belman 33. Interaction of the Aging Process with Neurobehavioral and Neuro-AIDS Conditions in the HAART Era, Karl Goodkin, Mauricio Concha, Beth D. Jamieson, Rosa Rebeca Molina, Enrique Lopez, Wenli Zheng, Deshratn Asthana, and W. David Hardy Section VI. Special Health Care Issues and Neuro-AIDS 34. Neurologic Aspects of Palliative Care for HIV/AIDS, Peter A. Selwyn and John Booss 35. Medico-Legal Issues in HIV/AIDS in the 21st Century, Soma Sahai-Srivastava 36. Global Issues in Neuro-AIDS and Their Evolution over the Future of the HAART Era, Bruce J. Brew