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The handbook of neuropsychiatric biomarkers, endophenotypes and genes (hardback), Softcover reprint of hardcover 1st ed. 2009 Volume I: Neuropsychological Endophenotypes and Biomarkers

Langue : Anglais

Coordonnateur : Ritsner Michael

Couverture de l’ouvrage The handbook of neuropsychiatric biomarkers, endophenotypes and genes (hardback)
Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances.This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: 'Neuropsychological Endophenotypes and Biomarkers' (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), 'Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers', 'Metabolic and Peripheral Biomarkers' and 'Molecular Genetic and Genomic Markers'. The contributors are internationally and nationally recognized researchers and experts from 16 countries.This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.
ForewordContributorsPart I. Methodological and Technological Advances1. Where do we stand in the quest for neuropsychiatric biomarkers and endophenotypes and what next? Michael S. Ritsner and Irving I. Gottesman2. Methodological and statistical issues in the use of biomarkers in clinical and research studies. Ryan Van Lieshout and Peter Szatmari3. Challenging the genetic complexity of schizophrenia by use of endophenotypes. Assen Jablensky4. Translational medicine: functional biomarkers for drug development of "cognitive enhancers" in schizophrenia. Georg Winterer5. Leveraging high-dimensional neuroimaging data in genetic studies of neuropsychiatric disease. Cinnamon S. Blos. Trygve E. Bakke. Alexander H. Joyne. Nicholas J. Schork6. Proteomics as a new tool for biomarker-discovery in neuropsychiatric disorders. Thomas J. Raedle. Harald Mischa. Holger Jah. Klaus Wiedemann7. Schizophrenia endophenotypes as treatment targets. Stephen I. Deutsc. Barbara L. Schwart. Richard B. Ross. John Mastropaol. Ayman H. Fanou. Abraham Weizma. Jessica A. Burke. Brooke L. GaskinsPart II. Neuropsychologica. Neurocognitive and Neurophysiological Domains8. Neuropsychological endophenotypes in schizophrenia and bipolar I disorder: yields from the Finnish family and twin studies. Annamari Tuulio-Henriksso. Jonna PerälÃ. Irving I. Gottesman and Jaana Suvisaari9. Is more cognitive experimental psychopathology of schizophrenia really necessary? Challenges and opportunities. Angus MacDonal. III10. Intellectual functioning as an endophenotype for schizophrenia. Odette de Wilde11. Emotion recognition deficits as a neurocognitive marker of schizophrenia liability. Renata Schoema. Dana J. H. Niehau. Liezl Koe. Jukka M. Leppänen12. The use of neurocognitive endophenotypes in large-scale family genetic studies of schizophrenia. William P. Hora. Tiffany A. Greenwoo. David L. Braf. Raquel E. Gur and Michael F. Green13. Neurocognitive endophenotype.nbs.for bipolar disorder: evidence from case-contro. family and twin studies. Eugenia Kravarit. Fergus Kan. Robin Murray14. Trait and state markers of schizophrenia in visual processing. Yue Che. Daniel Norton and Ryan McBain15. Visual scanning abnormalities as biomarker for schizophrenia and bipolar disorder. Patricia E. G. Bestelmeyer16. Biomarkers and endophenotypes in eating disorders. Carolina Lope. Marion Roberts and Janet Treasure17. Movement abnormalities: a putative biomarker of risk for psychosis. Vijay Mittal and Elaine WalkerAfterword by Robert H. BelmakerContents o.nbs.Volumes . . and 4Contributors of Volumes . . and 4Index

New tools for biomarker-discovery

Endophenotype strategy

Peripheral biomarkers for neuropsychiatric disorders

Neuroimaging biomarkers and endophenotypes

Neurocognitive biomarkers and endophenotypes

Pharmacogenetics and pharmacogenomics

Date de parution :

Ouvrage de 273 p.

19.3x26 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 147,88 €

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Date de parution :

19.3x26 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 126,55 €

Ajouter au panier
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