Targeted Molecular Imaging in Oncology, 2001

Cancer cells dedifferentiate with repect to cell function; their vascularity is more leaky, but perfusion is heterogenerously reduced, and interstitial fluid pressure is high, severely retarding delivery of agents from the blood. Targeted imaging is designed to produce a detectable difference between tissue that is visualized with single photon and positron emission tomography, magnetic resonance imaging, computed tomography, or ultrasonography. This book uniquely reports strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. This book also describes updated information about the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

1 Principles of Basic Sciences Related to Cancer.- 2 Imaging Strategies and Perspectives in Oncology.- 3 Principles of Single Photon Emission Computed Tomography and Positron Emission Tomography.- 4 Principles of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy.- 5 Radiopharmaceuticals for Tumor-Targeted Imaging: Overview.- 6 Antibodies for Targeted Imaging: Properties and Radiolabeling.- 7 Radioimmunodetection of Cancer.- 8 Peptide Receptor Imaging.- 9 Polymer-Based Compounds for Targeted Imaging.- 10 Targeted Single Photon Emission Computed Tomography in Oncology.- 11 Targeted Positron Emission Tomography in Oncology.- 12 Targeted Magnetic Resonance Imaging Contrast Agents.- 13 Magnetic Resonance Characteristics of Tumors.- 14 Targeted Imaging of Lymph Nodes.- 15 Computed Tomography and Ultrasound Contrast Agents.- 16 Imaging of Anticancer Drugs for Therapeutic Response and Prognosis.- 17 Imaging of Angiogenesis.- 18 Imaging of Apoptosis and Hypoxia.- 19 Imaging of Signal Transduction and Antisense Imaging.- 20 Imaging of Gene Delivery and Expression.- 21 Optical Imaging and In Vivo Microscope.