Systems Analysis of Human Multigene Disorders, 2014 Advances in Experimental Medicine and Biology Series, Vol. 799

Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

Wellness and Health Omics Linked to the Environment: the WHOLE approach to personalized medicine.- Characterizing Multi-omic Data in Systems Biology.- High-throughput Translational Medicine: Challenges and Solutions.- Computational approaches for human disease gene prediction and ranking.- A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization.- Index.

High-throughput experimental genomics technologies for data collection Bioinformatics approaches for systems-level analysis of biological systems and prediction of causative multidimensional patterns of inheritance characteristic of multigene disorders Case scenarios of systems-level analysis of multigene disorders