Syndromes of hormone resistance on the hypothalamic-pituitary-thyroid axis

This volume covers the most recent scientific findings of the syndromes of hormone resistance in the HPT axis, i.e., thyroid hormone resistance and resistance to TSH action. Mechanisms of action of the various hormones, etiopathology of the syndromes, instruments for diagnosis, as well as the difficulties in managing these diseases are covered. In general, these disorders of HPT axis are uncommon and thus difficult to diagnose and treat. As a result, this book is a useful resource to clinicians and helps delineate the clinical flow-chart for both diagnosis and treatment.

Preface.

1. Molecular basis of thyroid hormone action, P.M. Yen.

2. Tissues specific action of thyroid hormones: insights from knock out animal models, M. Plateroti, C. Angelin-Duclos, F. Flamant, J. Samarut.

3. Learning from nature's experiments on the thyroid hormone receptor, X-ray structures of RTH mutant ligand-binding domains, B.H. Sandler, J.D. Baxter, R.J. Fletterick.

4. Molecular pathogenesis of resistance to thyroid hormone, V.K.K. Chatterjee.

5. Syndromes of resistance to thyroid hormone: clinical aspects, D. Mannavola, P. Beck-Peccoz.

6. Resistance to thyroid hormone in the absence of mutations in the thyroid hormone receptor genes, S. Refetoff, P.M. Sadow, S. Reutrakul, K. Dennis, D. Mannavola, J. Pohlenz, R.E. Weiss.

7. Lessons learned from TR-beta mutant mice, F.E. Wondisford.

8. Towards the rational design of hormone analogs which complement receptor mutations, J.T. Koh, M.C. Putnam.

9. Multi-factorial regulation of in vivo action of TRbeta mutants. Lessons learned from RTH mice with a targeted mutation in the TRbeta gene, Sheue-yann Cheng.

10. The effect of vitamin A, retinoids and retinoid receptors on the hypothalamic-pituitary-thyroid axis, B.R. Haugen.

11. Pituitary resistance to thyroxine action due to a defect in the type 2 deiodinase, V.A. Galton.

12. Different forms of resistance to thyrotropin (TSH) action, L. Persani, D. Calebiro, T. de Filippis.

Index.