Stimulation and Inhibition of Neurons, Softcover reprint of the original 1st ed. 2013 Neuromethods Series, Vol. 78

Activation, inhibition, or destruction of the nervous system or its component parts as a vital tool for the investigation of function has undergone remarkable development; indeed, new approaches have been developed that allow for these actions to be used as therapeutic tools.  In Stimulation and Inhibition of Neurons, experts in the field provide an overview of modern methods for generating lesions as well as for stimulating and inhibiting neural pathways.  Many new techniques such as optogenetics and the use of the in situ perfused preparation are examined, while, in other sections, the use and validity of more well-known approaches are reassessed. Written for the Neuromethods series, chapters examine their respective topics thoroughly and include the kind of detail and implementation advice that ensures successful results in the laboratory.

Optogenetic Stimulation of Neurons in the Brainstem of Freely Behaving Rats and Mice.- Stimulating Peripheral Afferents to Evoke Cardiorespiratory Reflex responses in the In Situ Arterially-Perfused Preparation.- Excitatory Responses to Microinjection of Glutamate Depend on Dose not Volume: A Meta-Analysis of Studies in Rat RVLM.- Acute Activation and Inhibition of the Sympathetic Baroreceptor Reflex.- Pharmacological Dissection of G Protein-Mediated Second Messenger Cascades in Neurons.- In Vivo Manipulation of Intracellular Signalling Pathways.- Identification of Spinally Projecting Neurons in the Rostral Ventrolateral Medulla In Vivo.- Microionotophoretic Study of Individual Neurons During Intracellular Recording.- Neurobiotin Electroporation for Combined Structural and Functional Analysis of Neurons in Developing Mouse Brain Slices.- Juxtacellular Neuronal Labelling, Physiological Characterization, and Phenotypic Identification of Single Neurons In Vivo.- Analysis of Sympathetic Nerve Activity Analysis of Sympathetic Nerve Activity.- Insight into Autonomic Nervous System Control of Heart Rate in the Rat Using Analysis of Heart Rate Variability and Baroreflex Sensitivity.- Neurophysiological Recording of the Compound Muscle Action Potential for Motor Unit Number Estimation in Mice.- Animal Models of Neuropathic Pain Due to Nerve Injury.- Detection of Sensitized Nerve Responses: Dorsal Root Reflexes, Live Cell Calcium, and ROS Imaging.- Visual Evoked Potential Recording in Rodents.- The Visual Evoked Potential in Humans.- Improving Motor Activation Patterns after Stroke with Wii-Based Movement Therapy.