Stability and Characterization of Protein and Peptide Drugs, Softcover reprint of the original 1st ed. 1993 Case Histories Pharmaceutical Biotechnology Series, Vol. 5

This is the first volume to make available specific case histories of therapeutic proteins and peptides that have been marketed or are currently under clinical testing. The editors have selected a wide range of molecules derived from monoclonal antibodies, recombinant DNA, and natural and chemical sources to provide formulation scientists with practical examples of the deveopment of pharmaceutical products.

1 Stability and Characterization of Human Growth Hormone.- 2 Characterization and Formulation Considerations for Recombinantly Derived Bovine Somatotropin.- 3 Stability Characterization and Formulation Development of Alteplase, a Recombinant Tissue Plasminogen Activator.- 4 Orthoclone OKT3: Chemical Mechanisms and Functional Effects of Degradation of a Therapeutic Monoclonal Antibody.- 5 Leuprolide and Other LH-RH Analogues.- 6 Stability of Adrenocorticotropic Hormone (ACTH) and Pathways of Deamidation of Asparaginyl Residue in Hexapeptide Segments.- 7 Stability and Characterization of Human Interleukin-1?.- 8 Development and Shelf-Life Determination of Recombinant Interleukin-2 (Proleukin).- 9 Formulation and Stability of Recombinant ?1-Antitrypsin.- 10 Fibrolase: A Fibrinolytic Protein from Snake Venom.- 11 Insulin Structure and Stability.