Role of Capsaicin in Oxidative Stress and Cancer, 2013 Diet and Cancer Series, Vol. 3
Langue : Anglais
This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.
Preface.- Role of capsaicin in cancer prevention.- Role of death receptors belonging to the TNF family in capsaicin-induced apoptosis of tumorcells.- Role of capsaicin in prostate cancer.- Capsaicin and the urinary bladder.- Inhibition of pancreatitis and carcinogenesis by capsaicin.- Cytochrome P450-dependent modification of capsaicinoids: pharmacological inactivation and bioactivation mechanisms.- The cancer suppressing and promoting actions of capsaicin.- Oxidative stress by capsaicin in cancer.
Thoroughly reviews the preventive and therapeutic effects of capsaicin in melanoma, pancreatic cancer, colon cancer, breast cancer, lung cancer, multiple myeloma and others Identifies molecular and cellular targets of capsaicin and describes the role of mitochondria in capsaicin-mediated therapeutic effects Benefits medical students, oncologists and cancer researchers
Date de parution : 05-2015
Ouvrage de 178 p.
15.5x23.5 cm
Date de parution : 05-2013
Ouvrage de 178 p.
15.5x23.5 cm
Thèmes de Role of Capsaicin in Oxidative Stress and Cancer :
Mots-clés :
Cancer; Capsaicin; Oxidative stress; Prevention; Therapy; Apoptosis; gene expression
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