Revival: Respiratory Drug Delivery (1989) CRC Press Revivals Series

The focus of this book is on subjects related to drug delivery to the lung. The text spans topics from aerosol deposition through pharmaceutical chemistry and formulation to the final clinical evaluation of pharmaceutical products. Utilizing a multi-disciplinary approach, the chapters consider toxicology from the point of view of drugs and pharmaceutical excipients used in aerosols.

Chapter 1

Pathophysiological and Disease Constraints on Aerosol Delivery

Chapter 2

Toxicological Responses to Inhaled Aerosols and Their Ingredients

Chapter 3

Drug Application to the Respiratory Tract: Metabolic and Pharmacokinetic Considerations

Chapter 4

Pro-Drugs for Pulmonary Drug Targeting

Chapter 5

Absorption, Clearance, and Dissolution in the Lung

Chapter 6

Aerosol Formulation, Generation, and Delivery Using Nonmetered Systems

Chapter 7

Aerosol Formulation, Generation, and Delivery Using Metered Systems

Chapter 8

Clinical Testing of Aerosol Drugs

Appendix

The Effects of Water Inhalation Suspendion Aerosol Formulations

Index