Resistance to Immunotherapeutic Antibodies in Cancer, Softcover reprint of the original 1st ed. 2013 Strategies to Overcome Resistance Resistance to Targeted Anti-Cancer Therapeutics Series, Vol. 2

????The traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic. There have been encouraging results in alternative therapeutic approach called antibody-mediated anti-cancer therapy, which is less toxic, more selective, and can also reverse drug/radiation resistance. Monoclonal antibodies or mAbs can be used to destroy malignant tumor cells and prevent tumor growth by blocking specific cell receptors. mAbs can bind only to cancer cell-specific antigens and induce an immunological response against the target cancer cell. The book covers the common and unique features of mAbs agains various cancer, gives the latest developments on the molecular, biochemical and genetic mechanisms of resistance by various mAbs, as well as discuss novel mAbs to overcome resistance.

Preface.- Introduction and generation of chimeric and humanized mAbs.- mAbs targeted against cancer cells and antibodies targeted against the tumor microenvironment.- Antibodies directed against different major cancers: Effects when used  alone or in combination with drugs.- Mechanisms of antibodies-mediated responses, in vitro and in vivo.- Molecular Pathways.- Molecular Signatures.- Identification of resistance targets for intervention.- Various chemicals that can sensitize resistant tumor cells.- Other mAbs.- Proteasome inhibitors.- Divalent mAbs.- Antibodies coupled to chemical inhibitors.- Antibodies coupled to cytokines.- Nanoparticles with mAbs.- Index.

Dr. Benjamin Bonavida is a professor at UCLA's David Geffen School of Medicine for the Department of Microbiology, Immunology, & Molecular Genetics. His other appointments include being a member of the Department of Defense Congressionally Directed Medical Research Program, Member of the National Cancer Institute's SPORE Program, member of the International Scientific Advisory Board of the Israel Cancer Research Foundation, to name a few. He's currently a scientific reviewer for several journals and a member of editorial boards including Journal of Clinical Immunology, International Journal of Oncology, and Cancer Biotherapy & Radiopharmaceuticals. In his career, he's published over 450 papers and reviews, and he's also edited two books with Springer in the past. For more information, please see the CV attached herewith.

Summarizes common and unique features of mAbs against various cancers Explores the latest developments on the molecular, biochemical and genetic mechanisms of resistance by various mAbs Covers the potential use of the combination treatment of mAbs with other drugs/mAbs to reverse resistance Includes supplementary material: sn.pub/extras