Recent Advances in Management of Digestive Cancers, Softcover reprint of the original 1st ed. 1993 Proceedings of UICC Kyoto International Symposium on Recent Advances in Management of Digestive Cancers, March 31-April 2, 1993

Cancer is the leading cause of death in many countries, and digestive cancer is one of the most common types of neoplasms. Advances in research on the management of digestive cancer therefore represent an important contribution to the welfare of humankind throughout the world. The VICC Kyoto International Symposium on Recent Advances in the Management of Digestive Cancer was held in Kyoto from March 31 to April 2, 1993 under the presidency of Dr. T. Takahashi of the Kyoto Prefectural Vniversity of Medicine. At this event, leading researchers and clinicians presented new findings and the latest results of clinical trials concerning digestive cancers. The VICC President and other members of the Executive Committee of the VICC also gave speeches on their own fields, and more than 1000 participants from 28 countries were very well received. This book presents the proceedings of this symposium. In addition to 30 selected papers presented at special lectures and symposia by invited speakers, this book contains 230 free papers presented at poster sessions during this conference.

Special Lectures.- The Role of UICC in the Management of Cancer Patients.- Mechanisms for Organ Specific Metastasis, in Particular from the Gastro-Intestinal Tract to the Liver.- 1 Present and Prospective Trends of Digestive Cancers in the World.- Present and Prospective Trends of Digestive Cancer in Germany.- Present and Prospective Trends of Digestive Cancers in Korea.- Rise and Fall in Environmental Cancer Mortality and Suggestion to Prevention Programs.- Present and Prospective Trends of Digestive Cancers in the World (USA).- 2 Avoidability of Digestive Cancer.- Prevention of Digestive Cancers — The UICC Project on Evaluation of Primary Prevention.- The Role of Nutrition in the Cause and Prevention of Digestive Cancers.- Epidemiology of Stomach Cancer in Japan with Special Reference to the Relationship Between Atrophic Gastritis and Stomach Cancer.- Pathogen Oriented Prevention of Hepatocellular Carcinoma in Japan.- 3 Recent Advances in Early Detection and Treatment of Digestive Cancers.- Recent Advances in the Diagnosis and Treatment of Superficial Esophageal Cancer.- Recent Advances in Early Detection and Treatment of Gastric Cancer.- Early Detection of Colorectal Cancer and Advancement in Its Treatment in Japan.- Long-Term Results of a German Prospective Multicenter Study on Colo-Rectal Cancer.- Evaluation of Early Detection and Treatment of Hepatocellular Carcinoma.- Recent Advances in Diagnosis and Surgical Treatment of Pancreatic Cancer.- 4 Recent Strategies in the Treatment of Cancer Patients.- — Endoscopic and Laparoscopic Surgery.- Endoscopic Mucosal Resection for Early Carcinomas of the Esophagus.- Endoscopic Surgery for Gastric Cancer.- — New Technology for Cancer Surgery.- Radio-Immunoguided Surgery for Large Bowel Cancer.- Computer Assisted Surgery for Gastric Cancer.- Targeting Chemotherapy for Digestive Cancer Using Monoclonal Antibody Drug Conjugate.- — New Strategies for Cancer Therapy.- Hepatocellular Carcinoma: Hepatic Resection Versus Transplantation.- Inhibition of Vascularization in Cancer.- 5 Evaluation of Multidisciplinary Treatment of Patients with Digestive Cancers.- Evaluation of Efficacy of Chemotherapy/Radiation Therapy in the Treatment of Inoperative Gastric Cancer with Primary Foci.- Angiotensin II Induced Hypertension Chemotherapy (IHC) for Advanced Gastric Carcinoma.- Prerequisites of Adjuvant and Neoadjuvant Chemotherapy in Gastric Cancer.- Adjuvant Therapy of Gastric Cancer in the West.- Immunochemosurgery for Advanced Gastric Cancer.- Experimental and Clinical Results of Hyperthermo-Chemo-Radiotherapy in Esophageal and Rectal Carcinoma.- Esophagus.- — Histopathology.- Immunohistological Evaluation of the Presence of Keratins in Esophageal Cancer.- Immunohistochemical Evaluation of E-Cadherin and ?-Catenin Expression in Human Esophageal Cancer.- A Spectrophotometric Study of DNA Ploidy Patterns of Esophageal Squamous Cell Carcinoma.- Experimental Radioimmunodetection for Esophageal Carcinoma by Monoclonal Antibody KIS-l Fragment.- Synergistic Antitumoral Effects of ?12-Prostaglandin J2 and Recombinant Human TNF-? on Human Esophageal Cancer Cell Lines.- — Clinical Analysis.- Esophageal Carcinoma — An Analyses of 502 Cases.- Clinical Study of Superficial Esophageal Carcinoma.- Clinical Results of Transhiatal Esophagectomy for Carcinoma of the Lower Esophagus.- Esophagectomy in Geriatric Patients.- Effect of Postoperative Chemotherapy for Esophageal Carcinoma on Survival.- — Lymphnodes and Surgery.- Clinicopathological Evaluation of the Three-Field Lymph Node Dissection for Thoracic Esophageal Cancer.- The Surgical Significance of Proper Nodes Along the Right Laryngeal Nerve Chain Situated in the Supreme Portion of the Thorax, Designated as “Top Nodes”.- Total Pharyngolaryngoesophagectomy for Hypopharyngeal, Laryngeal, and Cervical Esophageal Carcinoma.- Reconstruction with Free Jejunal Autograft for Cervical Esophageal Stenosis.- Stomach.- — Carcinogenesis.- Evaluation of E-Cadherins in Growth Patterns of Gastric Cancer and Its Degree of Cell Differentiation.- Ornithine Decarboxylase Activity in Human Stomach Cancer.- Significance of Helicobacter Pylori in Gastrocarcinogenesis: Special Reference to Tissue IgA Antibody in Chronic Gastritis and Intestinal Metaplasia.- Risk of Cancer Development in the Gastric Remnant by B-II Resection.- Study on Cancer of the Gastric Remnant by the Type of Reconstruction at Previous Gastrectomy.- — Tumor Markers.- Tumor Markers (AFP, CEA, CA19-9, CA125) for Detecting Recurrence of Gastric Cancer.- Non-Anatomical Prognostic Factors for Gastric Cancer Patients: Significance of Tumor Markers.- Gastric Acid Secretion and Serum Gastrin Levels in Gastric Cancer.- Early Detection of ?-Fetoprotein Producing Gastric Cancer by Reverse Transcriptase-Polymerase Chain Reaction.- — Histopathology.- Preoperative Prediction of Gastric Cancer Extension by in Vitro Labelling Index of Bromodeoxyuridine.- Immunohistochemical Study of PCNA (Proliferating Cell Nuclear Antigen) in Gastric Cancer with Special Reference to Progression and Prognosis.- c-myc Gene Expression in Primary Gastric Cancer.- Expression of CD44 Molecule in Gastric Cancer.- Sialyl-Tn Antigen as a Predictor of Survival Time for Patients with Gastric Carcinoma.- Expression of Sialosyl Tn Antigen in Gastric Cancer.- Immunohistochemical Evaluation of ?-Catenin, Cadherin-Associated Intercellular Protein, Expression in Human Gastric Cancer.- Expression of Tenascin in Gastric Cancers and Their Clinicopathological Features.- Study of a Synthesized New Carbohydrate Antigen in Gastro-Intestinal Cancers.- Histochemical Study of the Extra-Cellular Stroma in Gastric Cancer.- The Value of Microvessels in the Tumor of Gastric Carcinoma.- — Clinical Analysis.- Diagnosis of Lymph Nodes with Metastasis from Stomach Cancer Using Ultrasonography.- Prognostic Factors for Gastric Cancer Patients — Alternation of the Significance in 6,540 Patients Treated over a 30-Year Period.- Clinicopathological Characteristics of Cases with Metastasis to Lower Mediastinal Lymph Nodes and Treatment in Gastric Cancer with Esophageal Invasion.- Surgical Approach for Gastric Cancer Extended to the Esophagus.- A New Surgical Approach for Resection of Cancer of Gastric Cardia.- — Lymphnodes and Surgery.- A Study on the Status of Lymph Node Motastasis in Cancer of the Upper Third Stomach.- Role of MMC-Adsorbed Activated Carbon (MMC-CH40) in Guiding Resection of the Lymph Nodes in Patients with Gastric Cancer.- MMC-CH40 Staining the Regional Lymphnodes in the Use of Radical Operation for Gastric Cancer.- The Evaluation of Intraoperative Injection of Microcarbon Particles to Extended Lymph Nodes Dissection for Gastric Cancer.- Is It Correct Whether Pancreato-Splenectomy Is Essential for Dissection and Removal of Lymph Nodes Along the Splenic Artery?.- Evaluation of Super Extensive Lymph Node Dissection (R4) for Advanced Gastric Cancer.- Metastasis to Minute Lymph Node in Gastric Cancer, Its Significance for Indication of Endoscopic or Local Surgical Treatments.- — Surgery and Cases.- Roux-en-Y End-to-Side Esophagojejunostomy with Stapler After Total Gastrectomy.- The Role of Absolute Noncurative Gastrectomy for Primary Gastric Cancer.- Proper Indication of Gastrectomy for the Gastric Carcinomas with Liver Metastasis.- Gastric Cancer Developing 40 Years After Simple Gastrojejunostomy.- A Rare Case of Huge Gastric Carcinoma with Extramural Growth.- Multidisciplinary Treatment of Gastric Endocrine Cell Carcinoma and Large Liver Metastasis.- — Pylorus Preserving Gastrectomy.- Limited Surgery for the Early Gastric Cancer.- Pylorus Preserving Gastrectomy (PPG) with Lymph Node Dissection for Early Gastric Cancer in the Middle Third of the Stomach.- Pylorus-Preserving Gastrectomy for Gastric Cancer.- Indication and Postoperative Evaluation of Pylorus Preserving Gastrectomy for Early Gastric Cancer.- Gallbladder Function After Pylorus Preserving Gastrectomy for Gastric Cancer.- Adverse Effects of Regurgitant Duodenal Content on the Mucosa of the Residual Stomach After Partial Gastrectomy.- — Early Gastric Cancer.- Early Stomach Cancer in Turkey.- Multiple Early Cancer of the Stomach.- Are There Any Pathologic Differences Between Mucosal and Submucosal Cancer of the Stomach?.- Recurrence of Early Gastric Cancer.- A Study of Rational Dissection of Regional Lymph Node in Early Gastric Cancer.- Study of Distribution of Minute Gastric Cancerous Foci in Multiple Early Gastric Cancer Cases — In Order to Decide the Extent of Gastric Resection.- Indication for Curative Endoscopic Mucosal Resection for Early Gastric Cancer: Analysis of 290 Surgical Cases.- — Chemotherapy.- Lymph Node — Targeting Delivery of Adriamycin by Liposomal Administration into Gastric Submucosa in Rabbits.- Anti-Cancer Effects of Preoperative Chemotherapy for Gastric Carcinoma — The Relationship Between Histopathological Effects and Thymidilate Synthetase Inhibition Rate (TSIR).- Neoadjuvant Chemotherapy for Far Advanced Scirrhous Carcinoma (Linitis Plastica) of the Stomach and Its Significance.- Neoadjuvant Chemotherapy (UFT·CDDP Therapy) for Borrmann 4 Type Gastric Carcinoma.- Effects of Neoadjuvant Chemotherapy on High-Grade Advanced Gastric Cancers.- Pharmacological Study of Continuously Infused Tegafur or 5-Fluorouracil in Treatments of Patients with Gastric Adenocarcinoma.- Adhesive Tumor Cell Culture System (ATCCS) — Chemosensitivity Assay in Gastric Cancer with Emphasis on the Possibility of Preoperative Analysis by Data of Gastrobiopsy.- Effects of Surgical Adjuvant Chemotherapy and Combined Resection of Adjacent Organs on the Survival Rate of Gastric Cancer Patients.- Evaluation of Combination Chemotherapy Using 5-FU, Leucovorin, and CDDP (FLP Therapy) Against Recurrent or Advanced Stomach Cancer.- — Immunotherapy.- Local Immunotherapy for Gastric Cancer Using a Mixture of OK-432 and Fibrinogen.- Intralymph Nodal Injection of the Mixture of OK-432 and Mitomycin C(MMC) Adsorbed onto Fine Activated Carbon Particles (CH40) for the Treatment of Lymph Node Metastasis.- Clinical and Immunological Effects of Locoregional Immunochemotherapy for Either Liver Metastases or Peritoneal Dissemination of Gastric Cancer.- Suppression of Cytokines Production in Peripheral and Regional Lymph Node Lymphocytes from Patients with Gastric Cancer and the Augmentative Effect of BRM.- Effect of Splenectomy on Prognosis in Immunochemotherapy After Total Gastrectomy for Gastric Cancer.- Immunosuppressive Acidic Protein and Postoperative Immunotherapy in Gastric Cancer.- Prevention of Growth of a Human Gastric Cancer Xenograft in Nude Mice with Anti-EGF Receptor Antibody.- Intraperitoneal Administration of Recombinant Interleukin-2 (rIL-2) Against Peritoneal Dissemination of Gastric Cancer.- The Prognostic Effect of the Immuno-Chemotherapy to Gastric Cancer with Peritoneal Metastasis.- Continuous Hyperthermic and Normothermic Peritoneal Perfusion for the Prevention of Peritoneal Recurrence of Gastric Cancer — A Randomized Control Study.- Peritoneum.- Establishment of Human Gastric Cancer Cell Line (SGC-7901) Intraperitoneally Transplantable in Nude Mice.- Effect of Laminin Receptor Ligands on Peritoneal Metastasis.- Adjuvant Intraperitoneal High-Dose Chemotherpay with Mitomycin C in Patients with Primary Advanced Gastric Cancer.- The Effects of Intraperitoneal Administration with High-Dose MMC and OK-432 Against Far Advanced Gastric Cancer.- Intraperitoneal Administration of Cisplatin for Patients with Gastric Cancer and Peritoneal Dissemination.- Intraperitoneal Cisplatin Microspheres for the Management of Malignant Ascites.- Endoscope.- — Diagnosis.- Role of Dye Endoscopy with Lugol in the Diagnosis of Esophageal Carcinoma.- Endoscopic Examination for the Early Esophageal Cancer in Patients with Head and Neck Cancers.- Effect of Routine Endoscopy on Critical Assessment in Diagnosis of Intestinal Metaplasia at Mexico General Hospital.- Management of Early Colorectal Carcinoma Defined by Endoscopic Findings.- Intraportal Endovascular Ultrasonography for Pancreatobiliary Carcinoma.- — Treatment.- New Endoscopic Mucosectomy Technique for Early Cancer of Esophagus, Stomach, and Colon.- Endoscopic Mucosal Resection of Early-Stage Esophageal Cancer.- The Elevated Type Early Gastric Cancer as the Subject of the Endoscopic Resection or the Conservative Surgical Operation.- Endoscopic Surgery for Early Gastric Cancer and the Points Which Demand Special Attention.- Endoscopic Treatment of Early Gastric Cancer and Evaluation of Submucosography in the Diagnosis of the Depth of Cancer Invasion.- Endoscopic Treatment for the Cancer and Submucosal Tumor of the Upper Gastrointestinal Tract.- Colon and Rectum.- — Carcinogenesis.- Characteristics of Cancer of the Large Bowel and Implication of Intestinal Flora and Bile Acids as Causal Factors.- Effect of Apple Pectin on Azoxymethane-Induced Colon Carcinogenesis — Fecal Enzyme Activities and Prostaglandin E2 Level in Colonic Mucosa.- Inhibitory Effect of Green Tea Extract Against Azoxymethane-Induced Colon Carcinogenesis in Rat.- Significance of Fecal Bile Acid Ratio in Colorectal Cancer Patients.- Effect of Short Chain Fatty Acids on Histopathological Type of Colon Cancer Induced by 1,2-Dimethylhydrazine in Rat.- Relationship Between Gastrin Receptor Values in Colorectal Cancer Tissues and Clinical Stage.- — Histopathology.- DNA Index and p53 Immunoreaction in Colorectal Cancer and Its Relationship to Prognosis.- Relationship Between Fecal Mutant p53 Protein and Colorectal Cancers.- Proliferating Cell Nuclear Antigen Expression in Colorectal Cancer According to the Depth of Invasion.- The Expression of Neural Cell Adhesion Molecule in Advanced Rectal Cancer.- Sialyl Lewis-X Antigen Expression in Human Colorectal Carcinomas: Relationship Between Expression Level and Prognosis.- A Scanning Electron Microscope Study of the Fibrous Stroma Adjacent to the Tumor Acini of Invasive Colonic Cancers.- — Tumor Markers.- Diagnostic Significance of Serum CEA and CA19-9 Levels in Colorectal Cancers.- Evaluation of Preoperative Serum CEA and IAP Levels in the Patients with Colorectal Cancer.- The Meanings of CEA in Gallbladder Bile in Colorectal Cancer.- The Relationship Between Metastatic Potential and the Expression of Sialyl Lewis A (CA 19-9) and Sialyl Lewis X Antigens in Colorectal Cancer.- Laminin Levels and Stage of Vascular Invasion as Predictive Factors of Liver Metastasis in Colon Cancer.- Elevated Serum Levels of Soluble Tumor Necrosis Factor Receptors in Patients with Colorectal Cancer.- — Clinical Analysis.- Prognosis of Colorectal Cancer Related to Histopathological Type and Stage.- A Clinicopathological Study of Surgically Treated Colorectal Cancer.- Prognostic Features of Colorectal Cancer in the Young Adult.- Surgical Treatment for Juvenile Colorectal Carcinoma (Below the Age of 40).- Early Invasive Colorectal Carcinoma — A Retrospective Study About Risk Factors of Nodal Metastasis.- Perioperative Blood Transfusion Adversely Affects Prognosis of Colorectal Cancer Patients.- — Surgery.- Laparoscopic-Assisted Partial Colectomy for Early Colon Carcinoma.- Local Recurrence After Local Excision of Early Rectal Cancer.- Management Of Colorectal Cancer.- Surgical Trial for Rectal Cancer Using a Tissue Expander in Association with Pelvic Partition to Prevent Radiation-Induced Bladder Dysfunction.- A Novel Method for Restoration of Postoperative Defecation Function in the Patients with the Lower Rectal Cancer.- — Recurrence.- Patterns of Recurrence in Rectal Carcinoma Following Curative Resection: What Did the Post-Operative Radiotherapy Do?.- The Role of Lateral Lymphnode Dissection in the Prevention of Recurrence for Rectal Cancer.- Indications of Operative Modalities and Analysis of Local Recurrence After Curative Surgery for Rectal Cancer.- Cryosurgical Treatment for Local Recurrence of Rectal Cancer.- An Application of 201Tl-SPECT for Evaluating in Carcinoma of Digestive Diseases (Thallium-Technetium Subtraction SPECT of Hepatobiliary Carcinoma).- Radioimmunoimaging of Local Recurrence of Rectal Cancer by Radiolabeled Mouse Monoclonal Antibody A7.- — Chemoimmunotherapy.- Investigation of Thymidylate Synthase Induction in Colorectal Carcinoma Tissues After Administration of Anticancer Drug, Fluorinated Pyrimidine Fluoride Derivatives.- Effect and Action Mechanism of Prostaglandin E2 on Proliferation of Human Colon Cancer Cells in Culture.- Combination Therapy with CPT-11 and Interferon-? Against Human Colon Carcinoma in Nude Mice.- Expressions of HLA and Adhesion Molecules in Colorectal Cancer and the Effects of Local Administration of Interferon (IFN) Gamma and OK-432.- A New Chemotherapy to Reduce the Local Recurrence of Rectal Cancer.- — Radiotherapy.- Preoperative 60Co High Dose Rate Intraluminal Radiotherapy for Advanced Lower Rectal Cancer.- Histopathological Assessment in Rectal Carcinoma with Preoperative High-Dose-Rate Intraluminal Brachytherapy.- Development of a Cisplatin Suppository for Regional Chemotherapy of Ano-Rectal Cancer.- Radiological Findings of Minute and Small Depressed Colorectal Neoplasm.- Liver Primary.- — Carcinogenesis.- Comparative Epidemiology of Liver Cirrhosis and Liver Cancer in Japan.- Prevalence of Hepatitis B, C and Delta Viral Markers in Turkish Patients with Hepatocellular Carcinoma.- Glutaminase and Glutamine Synthetase Activities During Azo-Dye Hepatocarcinogenesis in Rat.- Expression of the Antimetastatic Gene nm23 in Human Hepatocellular Carcinomas.- Decreased Frequency of Mitochondrial DNA Deletion in Hepatoma Developed from Cirrhotic Liver Detected by PCR Method.- The Significance of Biological Factors (DNA Ploidy Pattern, AgNOR Scores And Various Tumor Markers) in Cholangiocellular Carcinoma.- — Diagnosis.- Diagnosis of Small Hepatocellular Carcinoma: Significance of Ultrasound and Tumor Markers.- Evaluation of Ultrasonically Guided Liver Biopsy for the Diagnosis of Small Hepatocellular Carcinoma.- The Significance of the Determination of AFP-Isoform in the Early Diagnosis of Hepatocellular Carcinoma (HCC).- Intratumor Pressure in Hepatocellular Carcinoma.- Evaluation of Multislice Dynamic MRI of the Whole Liver by Turbo-FLASH Method.- Non-Invasive Quantification of Human Liver Neoplasms by Positron Emission Tomography (PET) Using C15O2 Steady State Method.- — Surgery.- Short-Term Results of Resection for Hepatocellular Carcinoma: A New Preoperative Combination Therapy.- Factors Affecting Long-Term Survival and Recurrence of Hepatocellular Carcinoma (HCC) After Hepatic Resection.- Indication Criteria of Hepatectomy for Hepatocellular Carcinoma Based on Long-Term Result.- Results of Hepatic Resection for Small Liver Cancer.- Adverse Relationship Between Blood Transfusion and Survival After Hepatectomy for Hepatocellular Carcinoma Using Microtaze.- Biliary Obstruction Due to Hepatocellular Carcinoma (HCC) — Report of Six Cases.- Comparison Between Portal Vein Branch Ligation and Embolization for Compensatory Hyperplasia of Unoccluded Hepatic Lobe.- Preoperative Portal Vein Embolization for Hepatocellular Carcinoma with Portal Thrombi.- Therapeutic Strategy for Advanced Hepatocellular Carcinoma Using Systemic Interleukin-2 Infusion and Local Low-Dose Irradiation.- Fundamental Studies on Direct Injection of Ethanol (Et)+ Polyethylene Glycol (PEG) Mixture into Hepatocellular Carcinoma (HCC) in Rats.- — Intervention.- Segmental/Subsegmental Hepatic Arterial Embolization — A New Therapy for Hepatocellular Carcinoma.- Factors Involved in the Resistance to Repeated Transcatheter Arterial Embolization for Hepatocellular Carcinoma.- A New Approach to the Treatment of Hepatocellular Carcinoma with Intrahepatic Metastases — Transarterial Immuno-Embolization (TIE) with OK-432 and Fibrinogen.- Effect of Intra-Arterial Injection of Mitoxantrone-Lipiodol Emulsion on Hepatocellular Carcinoma.- Treatment of Unresectable Hepatocellular Carcinoma by Intra-Arterial Infusion of THP-Adriamycin Under Occlusion of Hepatic Arterial Flow.- Combination of Hepatic Arterial Infusion Chemotherapy and Portal Vein Occlusion for Unresectable Hepatocellular Carcinoma.- Secondary.- — Surgery.- Tumor Marker Doubling Time of Liver Metastases from Stomach and Colonic Cancer and Its Clinical Significance.- Prognosis of Liver Metastases from Colorectal Cancer After Hepatectomy.- Hepatic Metastasectomy of Colorectal Cancer: Evaluation of 8 Years Result.- Extensive Surgery for Carcinoma Recurrence After Initial Hepatectomy for Liver Metastasis of Colorectal Carcinoma.- Prognostic Comparison of Hepatic Resection of Liver Metastases and Chemotherapy via the Portal Vein with Liposome-Entrapped Adriamycin for Unresectable Liver Metastases on Gastric Cancer.- Management of Metastatic Liver Cancer.- — Intervention.- A Study of Prophylactic Arterial Infusion Chemotherapy for Remnant Liver in Case of Resected Liver Metastasis from Colorectal Cancer.- Hepatic Arterial Infusion Therapy with Leucovorin and 5-Fluorouracil for Liver Metastasis of Gastric and Colorectal Cancer.- The Therapeutic Effects of Liposomal Adriamycin Pretreated with Lentinan.- Continuous Hepatic or Splenic Arterial Infusion of Recombinant Interleukin-2 (rIL-2) and Cyclophosphamide(CY) in Patients with Liver Metastasis of Colorectal Carcinoma and Hepatobiliary Carcinoma.- Effects of Serial Transarterial Infusion Chemotherapy Combination with Multi-BRM for Metastatic Liver Tumor.- A Simple New Method of Hyperthermo-Chemo-Hypoxic Isolated Liver Perfusion for Hepatic Metastasis.- — Chemotherapy.- Prophylactic Effects of Doxorubicin on Hepatic Recurrence of Colonic VX2 Cancer Lesions.- Effect of OK-432 for Prevention of Spontaneous Metastasis in the Liver.- Effects of Continuous Venous or Portal Administration of Carboplatin Against VX2 Tumor Metastasizing to the Liver.- Experimental Study on the Efficacy of Intrahepatic Arterial and Portal Venous Infusion of Anticancer Drugs to Inhibit the Growth of Portally Inoculated VX-2 Carcinoma.- Anti-Angiogenic Agent, AGM-1470 Inhibited Liver Metastasis of VX2 Carcinoma in Rabbits.- Anticancer Effects of an Angiogenesis Inhibitor (TNP-470) After Arterial Injection in Rabbits Bearing VX-2 Carcinoma.- — Others.- Liposomes Coated with Molecular Recognition Site Are Useful for Active Targeting Chemotherapy on Cancer Cells.- Augmentation of Uptake of Mitomycin C in the Tumor Tissue After Infusion of Plasma Treated with Protein A: A Model Study of Metastatic Liver Tumor Using Rabbits Bearing Vx2 Carcinoma.- Metastases Models of Human Colon Cancer in Congenitally Athymic Mice.- Adhesion of Human Cancer Cells to Vascular Endothelium Mediated by a Carbohydrate Antigen, SPan-1.- Pancreas.- — Surgery and/or Radiation.- Extended Pancreatectomy for Locally Advanced Pancreatic Cancer Involving the Portal Vein — Indications and Limitations.- Indications for Extended Radical Whipple Operation for Ductal Adenocarcinoma of the Head of the Pancreas.- Simultaneous Intraoperative Interstitial Hyperthermia and Intraoperative Electron Beam Radiation Therapy for Pancreatic Carcinoma.- Resection of Remote Metastases from Pancreatic Cancer in Patients Previously Treated with Radical Resection Combined with Intraoperative Radiation Therapy.- A Quantitative Analysis of Gastrointestinal Motility After Intraoperative High Dose Irradiation to Paraaortic Lymph Nodes in Dogs.- — Immunodetection.- Immunohistological Expression of Pancreatic Cancer Associated Mucin Antigen and Radioimmunodetection in Pancreatic Cancer.- Biodistribution and Imaging of Chimeric Fab Fragment of Anti-Carcinoembryonic Antigen (CEA) Monoclonal Antibody in Nude Mice Bearing Pancreatic Carcinoma Xenografts.- Biodistribution of Monoclonal Antibody Nd2 Following Administration of Several Routes.- Enhanced Antitumor Effect of Neocarzinostatin Conjugated to Monoclonal Antibody A7 on Human Pancreatic Carcinoma Grafted in Nude Mice.- TNF-?, IFN-? and Tegafur Combination Therapy for Advanced Pancreatic Cancer.- — Others.- Differential Diagnosis of the Cystic Lesion of the Pancreas.- Adjuvant Therapy Following Resection of Pancreatic Head Carcinoma According to the Histopathological and Biological Features.- Nuclear DNA Content and Short-Term Survival Analysis in Carcinoma of the Pancreas: A Study Using Flow Cytometry.- Long Term Prognosis and DNA Ploidy Pattern After Pancreatoduodenectomy for Cancer of the Head of the Pancreas.- Role of O-Linked Oligosaccharides and Sialic Acids in Pancreatic Cancer Cell Interaction with Extracellular Matrix.- Biliary.- UICC and Japanese Stage Classifications for Carcinoma of the Gallbladder.- Clinicopathologic Factors Influencing Survival of the Patients with Bile Duct Carcinoma: A Multivariate Statistical Analysis.- Gallbladder Cancer Associated with Anomalous Junction of the Pancreaticobiliary Ductal System Without Bile Duct Dilatation.- Detection and Surgical Treatment of Gallbladder Cancer Operated for Cholelithiasis.- Resection with Preoperative Radiation Therapy for Cancer of the Extrahepatic Bile Duct.- Radiation Therapy in the Treatment of Bile Duct Cancer.- Differentiation Therapy for Human Bile Duct Cancer.- Immunotherapy.- Significance of Membrane Lymphotoxin (mLT) Expressed on Killer Cells for Adoptive Immunotherapy.- The Generation of CD4 Cytotoxic T Lymphocyte Augmented by Immobilized Anti-CD3 Antibody and Interleukin-2.- HLA-DR Expression on Cancer Cells and T Cell Reaction in Colorectal Carcinoma.- Therapeutic Efficacy of a Tumor-Infiltrating Lymphocyte Clone in Combination with Soluble Tumor-Specific Transplantation Antigen and Cyclophosphamide.- Enhancement of Tumor Cell Susceptibility to Tumor-Infiltrating Lymphocyte by Treatment with Cisplatin.- Changes of Lymphocyte Subsets Following Various Surgical Stress.- Others.- Chemotherapy Induced Toxicity and Its Relation with Tissue DNA Synthesis: A Circadian Stage Dependent Study.- Leukopenia Due to 5-Fluorouracil (5-FU) Administration Is Improved by Glutamine Supplemented Elemental Diet (Gln-ED).- Gianturco-Rosch Expandable Metallic Biliary Stent Applied for Treatment of Biliary Strictures.- Statistical Reappraisal of Cancer Staging System.- Study on the Central Mechanism of Indomethacin for Relieving GI Cancer Pain.- Effects of TPN or Enteral Nutrition on Gallbladder Motor Function in Postoperative Gastric Cancer Patients.- Surgical Management of Digestive Cancers in Chronic Hemodialysis Patients.- List of Contributors.- Key Word Index.