Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis, Softcover reprint of the original 1st ed. 1980 Symposium held in Rome/Italy, April 3–6, 1979 Archives of Toxicology Series, Vol. 3

Dose Response Relationship in Long-Term Exposure to Low Levels of Carcinogens in Animals.- Epidemiological Studies of Occupational Carcinogens.- Incidence of Hepato-Carcinoma in Relation to Aflatoxin Intake.- Epidemiological Studies of Medically Used Drugs.- Estimation of the Risks of Ionising Radiation.- Discussion.- Dose Response Relationship of Carcinogenic Effects on Target Organs or Tissues.- Formation and Subsequent Repair of Alkylation Lesions in Tissues of Rodents Treated with Nitrosamines.- Dose-Response Relationship in the Primary Lesion of Strong Electrophilic Carcinogens.- Non Linear Pharmacokinetic Parameters Need to be Considered in High Dose/Low Dose Extrapolation.- Glutathione Thresholds in Reactive Metabolite Toxicity.- Dose Dependence of Early Cellular Changes During Liver Carcinogenesis.- Binding Kinetics of Vinyl Chloride and Vinyl Bromide at Very Low Doses.- Discussion.- Dose Response Relationship of Biochemical Mechanisms Affecting Species Differences in Response.- Enzymes Controlling Tissues Levels of Reactive Metabolites Including Irreversible Inactivations.- Activating Enzymes: Multiple Monooxygenase Forms with Different Substrate Preferences as Related to Toxic Effects.- Glucuronic Acid Conjugation in the Metabolism of Chemical Carcinogens by Rodent Cells.- Species Differences in Activating and Inactivating Enzymes Related to in Vitro Mutagenicity Mediated by Tissue Preparations from these Species.- The Ah Locus. A Gene with Possible Importance in Cancer Predictability.- Dose-Response Relationship of Rat Aryl Hydrocarbon Hydroxylase and Epoxide Hydratase Induction.- Repair.- Different Basic Mechanisms in DNA Repair.- Possible Determinants for the Differential Susceptibility of Mammalian Cells and Tissues to Chemical Carcinogens.- Reaction of Benzo(a)pyrene and 7,12-Dimethylbenz(a)anthracene with DNA of Various Rat Tissues in Vivo.- Discussion.- Risk Assessment.- Epidemiological and Animal Data as a Basis for Risk Assessment.- An Approach to the Assessment of the Risk to Man from DNA Damaging Agents.- Range of Experimental Evidence in Assessing Potential Human Carcinogenicity.- Procedures for Assessing Risk at Low Levels of Exposure.- Limited Usefulness of Mathematical Models for Assessing the Carcinogenic Risk of Minute Doses.- Discussion.- Summaries of the Chairmen.- Author Index.